Atic - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Gene

Mus musculus

Also known as 2610509C24Rik

Gene ID: 108147 | Gene type: protein coding

About Atic

Summary

Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Atic Products(1)

mRNA	Protein	Name
NM_026195.3	NP_080471.2	bifunctional purine biosynthesis protein ATIC

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables IMP cyclohydrolase activity	IMP IMP: Inferred from mutant phenotype	6480832	MGI
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IMP IMP: Inferred from mutant phenotype	26144885	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' AMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	26144885	MGI
involved in 'de novo' IMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	26144885	MGI
involved in 'de novo' XMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	26144885	MGI
involved in GMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	26144885	MGI
acts upstream of or within cellular response to interleukin-7	IDA IDA: Inferred from direct assay	29581031	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bifunctional purine biosynthesis protein ATIC

AICAR transformylase/inosine monophosphate cyclohydrolase

bifunctional purine biosynthesis protein PURH

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0485	Liensinine Diperchlorate	Inhibitor	99.96%	Phase 2
HY-135238	(rel)-RSD 921	Agonist	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990067	Evunzekibart	Inhibitor	97.02%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150252A	ATIC-IN-1 acetate	Inhibitor	99.96%	Unkown
HY-N1448	Vincetoxicoside B	Inhibitor	99.70%	Unkown
HY-29244	ATIC-IN-2	Inhibitor	≥98.0%	Unkown
HY-150252	ATIC-IN-1		99.69%	Unkown
HY-E70121	Succinyl-CoA synthetase		/	Unkown
HY-141324	Tetraethyl butane-1,4-diylbis(phosphoramidate)		/	Unkown
HY-RS01126	ATE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01156	ATIC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17124	Atic Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23569	Atic Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atic	NCBI	NCBI:471
Canis lupus familiaris	Atic	NCBI
Rattus norvegicus	Atic	NCBI	NCBI:81643
Macaca mulatta	Atic	NCBI	NCBI:694819

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