Amd1 - adenosylmethionine decarboxylase 1 Gene

Rattus norvegicus

Also known as Amd1a; Amd1b

Gene ID: 81640 | Gene type: protein coding

About Amd1

Summary

Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Amd1 Products(1)

mRNA	Protein	Name
NM_031011.4	NP_112273.3	S-adenosylmethionine decarboxylase proenzyme

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenosylmethionine decarboxylase activity	IDA IDA: Inferred from direct assay	1415709	RGD
enables putrescine binding	IDA IDA: Inferred from direct assay	21048303	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-adenosylmethionine metabolic process	IDA IDA: Inferred from direct assay	1415709	RGD
involved in polyamine metabolic process	IDA IDA: Inferred from direct assay	10430362	RGD
involved in spermidine biosynthetic process	IDA IDA: Inferred from direct assay	1415709	RGD
involved in spermidine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10712236	RGD
involved in spermine biosynthetic process	IDA IDA: Inferred from direct assay	1415709	RGD
involved in spermine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10712236	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

S-adenosylmethionine decarboxylase proenzyme

S-Adenosylmethionine decarboxylase 1B	S-adenosylmethionine decarboxylase 1
S-adenosylmethionine decarboxylase 1A	SAMDC
adoMetDC

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109561	Pegaptanib sodium	Inhibitor	98.09%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19720A	Emixustat hydrochloride		99.29%	Phase 3
HY-19720	Emixustat		98.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-15492	AG-13958	Inhibitor	99.71%	Unkown
HY-RS09498	NPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-15492A	AG-13958 (mono(hydrochloride))	Inhibitor	/	Unkown
HY-N0679S	Retinyl acetate-d3		/	Unkown
HY-RS00644	AMD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18124	Amd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24598	Amd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Amd1	NCBI	NCBI:262
Mus musculus	Amd1	NCBI	NCBI:11702

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