2. Gene
  3. Actn1 - actinin, alpha 1 Gene

Actn1 - actinin, alpha 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81634 | Gene type: protein coding

About Actn1

Summary

Enables cytoskeletal regulatory protein binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including actin Cytoskeleton organization; focal adhesion assembly; and platelet formation. Located in several cellular components, including cytoskeleton; dendritic spine; and nucleus. Colocalizes with cortical actin Cytoskeleton and stress fiber. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Actn1 Products(1)

mRNA Protein Name
NM_031005.4 NP_112267.1 alpha-actinin-1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytoskeletal regulatory protein binding IPI
IPI: Inferred from physical interaction
21210813 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14729062 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15140894 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell junction IDA
IDA: Inferred from direct assay
21210813 RGD
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
15505042 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
12223541 RGD
located in cytoskeleton IDA
IDA: Inferred from direct assay
21210813 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
12223541 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
21210813 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
16190873 RGD
is active in postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
16190873 RGD
located in stress fiber IDA
IDA: Inferred from direct assay
15505042 RGD
is active in synapse IDA
IDA: Inferred from direct assay
12223541 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-actinin-1

F-actin cross-linking protein

non-muscle alpha-actinin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1728A Super-TDU (1-31) TFA Inhibitor 99.27% Unkown
HY-P1728 Super-TDU (1-31) Inhibitor / Unkown
HY-RS00223 ACTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17075 Actn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23519 Actn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actn1 NCBI NCBI:87