Dhx58 - DEXH (Asp-Glu-X-His) box polypeptide 58 Gene

Mus musculus

Also known as LPG2; Lgp2; RLR-3; D11Lgp2e; B430001I08Rik

Gene ID: 80861 | Gene type: protein coding

About Dhx58

Summary

Enables double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]

Dhx58 Products(1)

mRNA	Protein	Name
NM_030150.2	NP_084426.2	ATP-dependent RNA helicase DHX58

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21703541	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	17475874	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	21525357	MGI
involved in negative regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	21525357	MGI
involved in positive regulation of MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	20080593	MGI
involved in positive regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	20080593	MGI
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	20080593	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in response to virus	IMP IMP: Inferred from mutant phenotype	20080593	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11735219	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

ATP-dependent helicase LGP2	RIG-I-like receptor 3
RIG-I-like receptor Lgp2	RLR
RNA helicase LGP2	probable ATP-dependent helicase LGP2
protein D11Lgp2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03759	DHX58 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21554	Dhx58 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dhx58	NCBI	NCBI:79132

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