Apaf1 - apoptotic peptidase activating factor 1 Gene

Rattus norvegicus

Gene ID: 78963 | Gene type: protein coding

About Apaf1

Summary

Enables heat shock protein binding activity and identical protein binding activity. Involved in several processes, including animal organ development; cardiac muscle cell apoptotic process; and cellular response to transforming growth factor beta stimulus. Located in cytoplasm. Part of apoptosome. Used to study visual epilepsy. Biomarker of brain ischemia; colon cancer; middle cerebral artery infarction; and muscular atrophy. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Apaf1 Products(1)

mRNA	Protein	Name
NM_023979.2	NP_076469.1	apoptotic protease-activating factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	22143029	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17483091	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16979168	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18197610	RGD
involved in cell differentiation	IEP IEP: Inferred from expression pattern	15504912	RGD
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	11003619	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	27665619	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18325779	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	14973070	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of apoptosome	IDA IDA: Inferred from direct assay	17483091	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apoptotic protease-activating factor 1

apaf-1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-126741	Azadirachtin		99.06%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18633	MDK83190	Activator	98.61%	Unkown
HY-100472	ZYZ-488	Inhibitor	99.80%	Unkown
HY-125018	QM31	Inhibitor	98.50%	Unkown
HY-Y0598	trans-Chalcone		98.65%	Unkown
HY-103349	PETCM		99.68%	Unkown
HY-116692	Apoptosis inducer 34		/	Unkown
HY-RS00801	APAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-171447	LPT99	Inhibitor	/	Unkown
HY-RS17757	Apaf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24224	Apaf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apaf1	NCBI	NCBI:317
Mus musculus	Apaf1	NCBI	NCBI:11783

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