2. Gene
  3. Akr1a1 - aldo-keto reductase family 1 member A1 Gene

Akr1a1 - aldo-keto reductase family 1 member A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Akr1a4

Gene ID: 78959 | Gene type: protein coding

About Akr1a1

Summary

Enables L-glucuronate reductase activity and glucuronolactone reductase activity. Involved in D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and cellular detoxification of aldehyde. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Akr1a1 Products(1)

mRNA Protein Name
NM_031000.3 NP_112262.1 aldo-keto reductase family 1 member A1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables L-glucuronate reductase activity IDA
IDA: Inferred from direct assay
22820017 RGD
enables glucuronolactone reductase activity IDA
IDA: Inferred from direct assay
22820017 RGD
Biological Process GO Annotation Evidence Reference Source
involved in D-glucuronate catabolic process IMP
IMP: Inferred from mutant phenotype
22820017 RGD
involved in L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
22820017 RGD
involved in cellular detoxification of aldehyde IDA
IDA: Inferred from direct assay
25152401 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
9538214 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member A1

3-DG-reducing enzyme

alcohol dehydrogenase

aldehyde reductase

glucuronate reductase

glucuronolactone reductase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 Inhibitor 99.79% Unkown
HY-N0310 Soyasaponin Bb 99.13% Unkown
HY-114009 AKR1C1-IN-1 Inhibitor 99.38% Unkown
HY-D1341 Coumberone 99.95% Unkown
HY-133708 β-Glucogallin 99.82% Unkown
HY-N8549A 5-Dihydrocortisone ≥99.0% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown
HY-113850 CPSA Inhibitor / Unkown
HY-131586 3,7-Dihydroxyflavone / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-172598 Keap1-Nrf2-IN-28 Inhibitor / Unkown
HY-173132 AKR1Cs-IN-1 Inhibitor / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17921 Akr1a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18415 Akr1d1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24390 Akr1a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24896 Akr1d1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1a1 NCBI NCBI:10327