2. Gene
  3. Slc25a12 - solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Gene

Slc25a12 - solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2610002D09Rik; B230107K20Rik

Gene ID: 78830 | Gene type: protein coding

About Slc25a12

Summary

Predicted to enable acidic amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Acts upstream of or within malate-aspartate shuttle. Located in mitochondrion. Is expressed in central nervous system; embryo; and retina. Used to study developmental and epileptic encephalopathy 39. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc25a12 Products(1)

mRNA Protein Name
NM_172436.5 NP_766024.1 electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acidic amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15987682 MGI
enables aspartate:glutamate, proton antiporter activity IMP
IMP: Inferred from mutant phenotype
15987682 MGI
Biological Process GO Annotation Evidence Reference Source
involved in malate-aspartate shuttle IDA
IDA: Inferred from direct assay
17213189 MGI
involved in malate-aspartate shuttle IGI
IGI: Inferred from genetic interaction
36967723 MGI
acts upstream of or within malate-aspartate shuttle IMP
IMP: Inferred from mutant phenotype
17213189 MGI
involved in malate-aspartate shuttle IMP
IMP: Inferred from mutant phenotype
15987682 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
15987682 MGI
is active in mitochondrial inner membrane IMP
IMP: Inferred from mutant phenotype
15987682 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14701727 MGI
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
17213189 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

calcium-binding mitochondrial carrier protein Aralar1

mitochondrial aspartate glutamate carrier 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13092 SLC25A12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20672 Slc25a12 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc25a12 NCBI NCBI:8604