2. Gene
  3. Knl1 - kinetochore scaffold 1 Gene

Knl1 - kinetochore scaffold 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Casc5; 2310043D08Rik; 5730505K17Rik

Gene ID: 76464 | Gene type: protein coding

About Knl1

Summary

Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Predicted to act upstream of or within cell division and chromosome segregation. Predicted to be located in acrosomal vesicle; kinetochore; and nuclear body. Predicted to be active in nucleus. Is expressed in telencephalon ventricular layer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly and primary autosomal recessive microcephaly 4. Orthologous to human KNL1 (kinetochore scaffold 1). [provided by Alliance of Genome Resources, Apr 2022]

Knl1 Products(2)

mRNA Protein Name
NM_001362732.1 NP_001349661.1 kinetochore scaffold 1 isoform 2
NM_029617.3 NP_083893.2 kinetochore scaffold 1 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in homologous chromosome orientation in meiotic metaphase I IMP
IMP: Inferred from mutant phenotype
35167144 MGI
involved in positive regulation of meiosis I spindle assembly checkpoint IMP
IMP: Inferred from mutant phenotype
35167144 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
35167144 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
35167144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinetochore scaffold 1

cancer susceptibility candidate 5

kinetochore-null protein 1

protein CASC5

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07412 KNL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22214 Knl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28736 Knl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Knl1 NCBI NCBI:57082