2. Gene
  3. Oga - O-GlcNAcase Gene

Oga - O-GlcNAcase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hy5; Mgea5; Ncoat

Gene ID: 76055 | Gene type: protein coding

About Oga

Summary

Predicted to enable beta-N-acetylglucosaminidase activity and Histone Acetyltransferase activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Predicted to be located in cytosol and mitochondrion. Is expressed in brain ventricular layer; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]

Oga Products(5)

mRNA Protein Name
NM_001403349.1 NP_001390278.1 protein O-GlcNAcase isoform 2
NM_001403351.1 NP_001390280.1 protein O-GlcNAcase isoform 3
NM_001403352.1 NP_001390281.1 protein O-GlcNAcase isoform 4
NM_001403353.1 NP_001390282.1 protein O-GlcNAcase isoform 5
NM_023799.5 NP_076288.1 protein O-GlcNAcase isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16356930 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein O-GlcNAcase

N-acetyl-beta-D-glucosaminidase

N-acetyl-beta-glucosaminidase

beta-N-acetylhexosaminidase

beta-hexosaminidase

bifunctional protein NCOAT

meningioma expressed antigen 5 (hyaluronidase)

meningioma-expressed antigen 5

nuclear cytoplasmic O-GlcNAcase a

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-144681 Ceperognastat Inhibitor 99.09% Phase 2
HY-130121 MK-8719 99.55% Phase 1
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12588 Thiamet G Inhibitor 99.99% Unkown
HY-108241 (Z)-PUGNAc 99.13% Unkown
HY-156586 Egalognastat Inhibitor 99.63% Unkown
HY-139431 NAG-thiazoline Inhibitor 98.08% Unkown
HY-131979 TP-040 98.59% Unkown
HY-108032 Hydroxyectoin Inhibitor ≥95.0% Unkown
HY-144682 (2R,4R)-LY3372689 / Unkown
HY-148240 JNJ-65355394 Inhibitor / Unkown
HY-161953 O-GlcNAcase-IN-2 Inhibitor / Unkown
HY-108246 GlcNAcstatin Inhibitor / Unkown
HY-144681A rel-Ceperognastat Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oga NCBI NCBI:10724
Canis familiaris Oga NCBI NCBI:477802
Susscrofa domestica Oga NCBI
Rattus norvegicus Oga NCBI NCBI:154968