OGA - Oga O-GlcNAcase Gene

Rattus norvegicus

Also known as Mgea5; Ncoat

Gene ID: 154968 | Gene type: protein coding

About OGA

Summary

Enables beta-N-acetylglucosaminidase activity and Histone Acetyltransferase activity. Involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Located in mitochondrion. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]

OGA Products(1)

mRNA	Protein	Name
NM_131904.2	NP_571979.1	protein O-GlcNAcase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-N-acetylglucosaminidase activity	IDA IDA: Inferred from direct assay	19004814	RGD
enables histone acetyltransferase activity	IMP IMP: Inferred from mutant phenotype	15485860	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acetylglucosamine metabolic process	IMP IMP: Inferred from mutant phenotype	19139380	RGD
involved in dATP metabolic process	IMP IMP: Inferred from mutant phenotype	17573462	RGD
involved in negative regulation of cardiac muscle adaptation	IMP IMP: Inferred from mutant phenotype	17573462	RGD
involved in negative regulation of protein glycosylation	IMP IMP: Inferred from mutant phenotype	16332679	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	16000877	RGD
involved in positive regulation of DNA metabolic process	IMP IMP: Inferred from mutant phenotype	19139380	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16899550	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	19139380	RGD
involved in positive regulation of calcium ion transport into cytosol	IMP IMP: Inferred from mutant phenotype	16107505	RGD
involved in positive regulation of cell killing	IMP IMP: Inferred from mutant phenotype	19139380	RGD
involved in positive regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	12242036	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17095531	RGD
involved in positive regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	19139380	RGD
involved in positive regulation of protein-containing complex disassembly	IMP IMP: Inferred from mutant phenotype	17573462	RGD
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	17573462	RGD
involved in protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	16000877	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	19139380	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein O-GlcNAcase

N-acetyl-beta-D-glucosaminidase	N-acetyl-beta-glucosaminidase
beta-N-acetylhexosaminidase	beta-hexosaminidase
bifunctional protein NCOAT	meningioma expressed antigen 5 (hyaluronidase)
meningioma-expressed antigen 5	nuclear cytoplasmic O-GlcNAcase a

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144681	Ceperognastat	Inhibitor	99.09%	Phase 2
HY-130121	MK-8719		99.55%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12588	Thiamet G	Inhibitor	99.99%	Unkown
HY-108241	(Z)-PUGNAc		99.13%	Unkown
HY-156586	Egalognastat	Inhibitor	99.63%	Unkown
HY-139431	NAG-thiazoline	Inhibitor	98.08%	Unkown
HY-131979	TP-040		98.59%	Unkown
HY-108032	Hydroxyectoin	Inhibitor	≥95.0%	Unkown
HY-144682	(2R,4R)-LY3372689		/	Unkown
HY-148240	JNJ-65355394	Inhibitor	/	Unkown
HY-161953	O-GlcNAcase-IN-2	Inhibitor	/	Unkown
HY-108246	GlcNAcstatin	Inhibitor	/	Unkown
HY-144681A	rel-Ceperognastat	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	OGA	NCBI	NCBI:10724
Canis familiaris	OGA	NCBI	NCBI:477802
Mus musculus	OGA	NCBI	NCBI:76055
Susscrofa domestica	OGA	NCBI

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