2. Gene
  3. Brsk2 - BR serine/threonine kinase 2 Gene

Brsk2 - BR serine/threonine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SADA; SAD-A; 4833424K13Rik

Gene ID: 75770 | Gene type: protein coding

About Brsk2

Summary

Enables protein kinase binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in several processes, including microtubule Cytoskeleton organization involved in establishment of planar polarity; regulation of axonogenesis; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within neuron projection morphogenesis and peptidyl-serine phosphorylation. Predicted to be located in distal axon and endoplasmic reticulum. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including central nervous system and retina. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Brsk2 Products(4)

mRNA Protein Name
NM_001009929.3 NP_001009929.1 serine/threonine-protein kinase BRSK2 isoform beta
NM_001009930.3 NP_001009930.1 serine/threonine-protein kinase BRSK2 isoform gamma
NM_001276763.1 NP_001263692.1 serine/threonine-protein kinase BRSK2 isoform delta
NM_029426.2 NP_083702.1 serine/threonine-protein kinase BRSK2 isoform alpha
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20026642 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17482548 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15705853 MGI
enables tau-protein kinase activity IDA
IDA: Inferred from direct assay
15705853 MGI
Biological Process GO Annotation Evidence Reference Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
17482548 MGI
acts upstream of or within establishment of cell polarity IGI
IGI: Inferred from genetic interaction
15705853 MGI
involved in establishment of cell polarity IGI
IGI: Inferred from genetic interaction
15705853 MGI
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
17482548 MGI
involved in microtubule cytoskeleton organization involved in establishment of planar polarity IGI
IGI: Inferred from genetic interaction
18268107 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
15705853 MGI
involved in neuron differentiation IGI
IGI: Inferred from genetic interaction
15705853 MGI
acts upstream of or within neuron projection morphogenesis IGI
IGI: Inferred from genetic interaction
20026642 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
20026642 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15705853 MGI
involved in regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
18268107 MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22798068 MGI
involved in regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
18268107 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase BRSK2

BR serine/threonine-protein kinase 2

brain-specific serine/threonine-protein kinase 2

serine/threonine-protein kinase SAD-A

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-18174 Prexasertib 98.74% Phase 2
HY-18174A Prexasertib dihydrochloride 99.41% Phase 2
HY-18174E Prexasertib dimesylate 99.04% Phase 2
HY-18174B Prexasertib Mesylate Hydrate / Phase 2
HY-18174C Prexasertib mesylate / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01638 BRSK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-18174H Prexasertib lactate / Unkown
HY-RS17337 Brsk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23792 Brsk2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brsk2 NCBI NCBI:9024