VIPR1 - vasoactive intestinal peptide receptor 1 Gene

Homo sapiens

Also known as II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2

Gene ID: 7433 | Gene type: protein coding

About VIPR1

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,489,299-42,537,568 (from NCBI)

This gene has 17 transcripts (splice variants), 194 orthologues and 42 paralogues. Broad expression in lung (RPKM 17.1), duodenum (RPKM 12.7) and 17 other tissues.

Summary

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates Adenylate Cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

VIPR1 Products(5)

mRNA	Protein	Name
NM_001251882.2	NP_001238811.1	vasoactive intestinal polypeptide receptor 1 isoform 2
NM_001251883.2	NP_001238812.1	vasoactive intestinal polypeptide receptor 1 isoform 3
NM_001251884.2	NP_001238813.1	vasoactive intestinal polypeptide receptor 1 isoform 4
NM_001251885.2	NP_001238814.1	vasoactive intestinal polypeptide receptor 1 isoform 5
NM_004624.4	NP_004615.2	vasoactive intestinal polypeptide receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	8390245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA
enables vasoactive intestinal polypeptide receptor activity	IDA IDA: Inferred from direct assay	8390245	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA IDA: Inferred from direct assay	8390245	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VIPR1 Protein Structure

HRM

7tm_2

0
100
200
300
400
457 a.a.

Protein Preferred Names

Protein Names

vasoactive intestinal polypeptide receptor 1

PACAP type II receptor

VIPR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VIPR1	P32241	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Prey Pooling	32296183
Intra	VIPR1	P32241	PRDM5	Homo sapiens	Q9NQX1-2	Validated Y2H	32296183
Intra	VIPR1	P32241	PRDM5	Homo sapiens	Q9NQX1-2	Y2H Array	32296183
Intra	VIPR1	P32241	P01282-PRO_0000011460	Homo sapiens	P01282-PRO_0000011460	SPA	23597562

Cross: Cross-species interaction Intra: Intraspecies interaction

VIPR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81524	VIPR1 Antibody (YA1269)	IHC-P	Human

Related Diseases

Diseases

Alias

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Achalasia

Cardiospasm	Achalasia Of Cardia
Esophageal Achalasia	Hypertensive Lower Esophageal Sphincter
Idiopathic Achalasia	Achalasia Cardia
Idiopathic Achalasia Of Esophagus	Primary Achalasia
Achalasia Of Esophagus	Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter
Aperistalsis Of The Oesophagus	Achalasia Of Oesophagus
Oesophageal Achalasia	Achalasia Nos
Cardia Spasm	Cardia Achalasia
Oesophageal Cardiospasm	Oesophagus Achalasia
Reflex Cardiospasm

Gastric Leiomyoma

Leiomyoma Of The Stomach

Parkinson Disease 14, Autosomal Recessive

PARK14	Dystonia-Parkinsonism, Adult-Onset
Autosomal Recessive Parkinson Disease 14	Parkinson'S Disease 14
Dystonia-Parkinsonism Adult-Onset	Adult-Onset Dystonia-Parkinsonism
Dystonia-Parkinsonism, Paisan-Ruiz Type	Pla2g6-Related Dystonia-Parkinsonism
Parkinson Disease 14	Autosomal Recessive Parkinson'S Disease 14
Nbia/Dyt/Park-Pla2g6	Dystonia-Parkinsonism Paisan-Ruiz Type
Parkinson Disease 14 Autosomal Recessive	Parkinson Disease, Type 14

Shigellosis

Dysentery, Bacillary	Bacillary Dysentery
Shigella Boydii Infectious Disease	Shigella Flexneri Infectious Disease
Shigella Gastroenteritis	Shigella Sonnei Infectious Disease
Shigella Infections

Tremor, Hereditary Essential, 2

ETM2	Essential Tremor 2
Essential Tremor, Hereditary, 2	Hereditary Essential Tremor 2
Tremor Hereditary Essential, 2

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15655	VIPR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22914	Vipr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	VIPR1	RGD	RGD:3961
Mus musculus	VIPR1	MGD	MGI:109272
Bos taurus	VIPR1	VGNC	VGNC:36799
Canis familiaris	VIPR1	VGNC	VGNC:48265
Felis catus	VIPR1	VGNC	VGNC:66945
Macaca mulatta	VIPR1	VGNC	VGNC:78771

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