Errfi1 - ERBB receptor feedback inhibitor 1 Gene

Mus musculus

Also known as Mig6; RALT; Mig-6; 1300002F13Rik

Gene ID: 74155 | Gene type: protein coding

About Errfi1

Summary

Predicted to enable SH3 domain binding activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including lung development; negative regulation of epidermal growth factor-activated receptor activity; and skin morphogenesis. Located in cytoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in alveolar system; lung; and lung epithelium. Used to study endometrial Cancer and osteoarthritis. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Errfi1 Products(2)

mRNA	Protein	Name
NM_001356323.1	NP_001343252.1	ERBB receptor feedback inhibitor 1
NM_133753.2	NP_598514.1	ERBB receptor feedback inhibitor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	22975324	MGI
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	20418913	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	22975324	MGI
acts upstream of or within bile acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	22912762	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	24550287	MGI
acts upstream of or within cell cycle	IMP IMP: Inferred from mutant phenotype	25976672	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	16247031	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	16247031	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	22912762	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	22912762	MGI
acts upstream of or within chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	24550287	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	20018910	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19683494	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22136853	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25976672	MGI
acts upstream of or within epithelium development	IMP IMP: Inferred from mutant phenotype	16819504	MGI
acts upstream of or within fat pad development	IMP IMP: Inferred from mutant phenotype	28053990	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	20418913	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	19439667	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	28053990	MGI
acts upstream of or within limb joint morphogenesis	IMP IMP: Inferred from mutant phenotype	24550287	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	22912762	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	22912762	MGI
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	19710174	MGI
involved in lung epithelium development	IMP IMP: Inferred from mutant phenotype	19710174	MGI
involved in lung vasculature development	IMP IMP: Inferred from mutant phenotype	19710174	MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19710174	MGI
involved in negative regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	16648858	MGI
acts upstream of or within negative regulation of protein kinase activity by regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	20418913	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	29843645	MGI
acts upstream of or within progesterone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25976672	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22136853	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	29843645	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22136853	MGI
involved in regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	16648858	MGI
acts upstream of or within regulation of protein binding	IDA IDA: Inferred from direct assay	29843645	MGI
acts upstream of or within regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	22975324	MGI
acts upstream of or within regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	20018910	MGI
acts upstream of or within response to 1-oleoyl-sn-glycerol 3-phosphate	IDA IDA: Inferred from direct assay	19683494	MGI
acts upstream of or within response to estradiol	IDA IDA: Inferred from direct assay	20018910	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	28053990	MGI
acts upstream of or within response to progesterone	IDA IDA: Inferred from direct assay	20018910	MGI
acts upstream of or within response to progesterone	IMP IMP: Inferred from mutant phenotype	25976672	MGI
acts upstream of or within response to steroid hormone	IMP IMP: Inferred from mutant phenotype	19439667	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	19683494	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	17987665	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	17987665	MGI
involved in skin morphogenesis	IMP IMP: Inferred from mutant phenotype	16648858	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	19439667	MGI
acts upstream of or within uterine epithelium development	IMP IMP: Inferred from mutant phenotype	19439667	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	17987665	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16648858	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16648858	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ERBB receptor feedback inhibitor 1

mitogen-inducible gene 6 protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04516	ERRFI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19775	Errfi1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26272	Errfi1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Errfi1	NCBI	NCBI:54206

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