Nfatc4 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Gene

Mus musculus

Also known as Nfat3; 3110041H08Rik

Gene ID: 73181 | Gene type: protein coding

About Nfatc4

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; long-term memory; and long-term synaptic potentiation. Acts upstream of or within several processes, including circulatory system development; intracellular signal transduction; and negative regulation of cellular component organization. Located in cytosol and nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc4 Products(2)

mRNA	Protein	Name
NM_001168346.1	NP_001161818.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 2
NM_023699.3	NP_076188.3	nuclear factor of activated T-cells, cytoplasmic 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12796475	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17242187	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16644691	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12796475	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19538478	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19538478	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	19179536	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22586092	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	11439183	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	19179536	MGI
acts upstream of or within cellular respiration	IDA IDA: Inferred from direct assay	12750314	MGI
acts upstream of or within cellular response to UV	IGI IGI: Inferred from genetic interaction	17242187	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	20530871	MGI
acts upstream of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23407945	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	12750314	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	17242187	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	17242187	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	22586092	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	22586092	MGI
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	21880741	MGI
acts upstream of or within negative regulation of chromatin binding	IDA IDA: Inferred from direct assay	23407945	MGI
acts upstream of or within negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23407945	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22586092	MGI
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	21880741	MGI
acts upstream of or within negative regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	23407945	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16644691	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18354019	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	20530871	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18354019	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16803872	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19538478	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16803872	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12796475	MGI
acts upstream of synapse maturation	IMP IMP: Inferred from mutant phenotype	23407945	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of or within vascular associated smooth muscle cell development	IGI IGI: Inferred from genetic interaction	11439183	MGI
acts upstream of or within vascular associated smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	11439183	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24970700	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16803872	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11439183	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	20385772	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 4

NF-AT3	NF-ATc4
T-cell transcription factor NFAT3	transcription complex subunit NF-ATc4

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0254	Kisspeptin-10, human		99.68%	Unkown
HY-P0254A	Kisspeptin-10, human TFA		99.85%	Unkown
HY-RS09242	NFATC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21899	Nfatc4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfatc4	NCBI	NCBI:4776

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