Slc17a7 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 Gene

Mus musculus

Also known as Vglut1; 2900052E22Rik

Gene ID: 72961 | Gene type: protein coding

About Slc17a7

Summary

Enables extracellularly glutamate-gated Chloride Channel activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within several processes, including chemical synaptic transmission; long-term memory; and sequestering of neurotransmitter. Located in several cellular components, including cerebellar mossy fiber; excitatory synapse; and synaptic vesicle membrane. Is expressed in several structures, including brain; retina layer; and spinal cord dorsal horn. Orthologous to human SLC17A7 (solute carrier family 17 member 7). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a7 Products(1)

mRNA	Protein	Name
NM_182993.2	NP_892038.2	vesicular glutamate transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate uniporter activity	IDA IDA: Inferred from direct assay	25433636	MGI
enables chloride channel activity	IDA IDA: Inferred from direct assay	25433636	MGI
enables extracellularly glutamate-gated chloride channel activity	IDA IDA: Inferred from direct assay	19169251	MGI
enables phosphate ion uniporter activity	IDA IDA: Inferred from direct assay	29642010	MGI
enables sodium:phosphate symporter activity	IDA IDA: Inferred from direct assay	29642010	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within L-glutamate import	IDA IDA: Inferred from direct assay	15860731	MGI
acts upstream of or within L-glutamate import	IGI IGI: Inferred from genetic interaction	15860731	MGI
acts upstream of or within L-glutamate import	IMP IMP: Inferred from mutant phenotype	15118123	MGI
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	25433636	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17611277	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15118123	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15118123	MGI
acts upstream of or within long-term memory	IMP IMP: Inferred from mutant phenotype	17241289	MGI
acts upstream of or within maintenance of location in cell	IMP IMP: Inferred from mutant phenotype	15103023	MGI
involved in neurotransmitter loading into synaptic vesicle	IDA IDA: Inferred from direct assay	15118123	MGI
involved in neurotransmitter loading into synaptic vesicle	IMP IMP: Inferred from mutant phenotype	15118123	MGI
involved in phosphate ion homeostasis	IDA IDA: Inferred from direct assay	33440152	MGI
involved in phosphate ion transmembrane transport	IDA IDA: Inferred from direct assay	29642010	MGI
involved in phosphate ion transport	IDA IDA: Inferred from direct assay	29642010	MGI
acts upstream of or within sequestering of neurotransmitter	IMP IMP: Inferred from mutant phenotype	15103023	MGI
involved in sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	29642010	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	15118123	MGI
acts upstream of or within synaptic vesicle lumen acidification	IMP IMP: Inferred from mutant phenotype	19169251	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cerebellar mossy fiber	IDA IDA: Inferred from direct assay	23791195	MGI
located in excitatory synapse	IDA IDA: Inferred from direct assay	16980967	MGI
located in presynaptic active zone	IDA IDA: Inferred from direct assay	18986540	MGI
located in synapse	IDA IDA: Inferred from direct assay	15118123	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	15579147	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	15860731	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicular glutamate transporter 1

brain-specific Na(+)-dependent inorganic phosphate cotransporter

solute carrier family 17 member 7

Slc17a7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87140	VGluT1 Antibody (YA6833)	WB, IHC-P	Mouse, Rat
HY-P87141	VGluT1 Antibody (YA6834)	IHC-F, IHC-P, WB	Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13040	SLC17A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc17a7	NCBI	NCBI:57030

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