Faim2 - Fas apoptotic inhibitory molecule 2 Gene

Mus musculus

Also known as Lfg; Lfg2; NMP25; Nmp35; Tmbim2; 2900002L20Rik

Gene ID: 72393 | Gene type: protein coding

About Faim2

Summary

Involved in cerebellar Purkinje cell differentiation; cerebellar granular layer development; and regulation of neuron apoptotic process. Acts upstream of or within negative regulation of apoptotic signaling pathway; negative regulation of neuron apoptotic process; and response to ischemia. Located in Golgi apparatus; endoplasmic reticulum; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and white fat. Orthologous to human FAIM2 (Fas apoptotic inhibitory molecule 2). [provided by Alliance of Genome Resources, Apr 2022]

Faim2 Products(2)

mRNA	Protein	Name
NM_001038658.2	NP_001033747.1	protein lifeguard 2 isoform 2
NM_028224.4	NP_082500.2	protein lifeguard 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26582200	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21209208	MGI
involved in cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	21957071	MGI
involved in cerebellar Purkinje cell layer development	IMP IMP: Inferred from mutant phenotype	21957071	MGI
involved in cerebellar granular layer development	IMP IMP: Inferred from mutant phenotype	21957071	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	21957071	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21209208	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21209208	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21209208	MGI
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17635665	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	21209208	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	26582200	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26582200	MGI
located in membrane	IDA IDA: Inferred from direct assay	26582200	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	17635665	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein lifeguard 2

neural membrane protein 35

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04675	FAIM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20922	Faim2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27439	Faim2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Faim2	NCBI	NCBI:23017

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