1. Gene
  2. Sfpq - splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Gene

Sfpq - splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Gene

Mus musculus

Also known as PSF; REP1; Gm12940; D4Ertd314e; 1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik

Gene ID: 71514 | Gene type: protein coding

About Sfpq

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including dendritic transport of messenger ribonucleoprotein complex; histone H3 deacetylation; and negative regulation of circadian rhythm. Acts upstream of or within cellular response to DNA damage stimulus; chromosome organization; and positive regulation of sister chromatid cohesion. Located in paraspeckles. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; lung mesenchyme; sensory organ; and testis. Orthologous to human SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Apr 2022]

Sfpq Products(1)

mRNA Protein Name
NM_023603.3 NP_076092.1 splicing factor, proline- and glutamine-rich
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
19389484 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18495661 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
21680841 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
20813759 MGI
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
21680841 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
20813759 MGI
involved in dendritic transport of messenger ribonucleoprotein complex IDA
IDA: Inferred from direct assay
15312650 MGI
involved in dendritic transport of messenger ribonucleoprotein complex IMP
IMP: Inferred from mutant phenotype
15312650 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22966205 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21680841 MGI
involved in negative regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
21680841 MGI
acts upstream of or within positive regulation of sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
20813759 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
20813759 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22966205 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
19389484 MGI
located in paraspeckles IDA
IDA: Inferred from direct assay
21444682 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

splicing factor, proline- and glutamine-rich

DNA-binding p52/p100 complex, 100 kDa subunit

PTB-associated splicing factor

polypyrimidine tract-binding protein-associated-splicing factor

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfpq NCBI NCBI:6421