Trim32 - tripartite motif-containing 32 Gene

Mus musculus

Also known as 3f3; BBS11; Zfp117; 1810045E12Rik

Gene ID: 69807 | Gene type: protein coding

About Trim32

Summary

Enables several functions, including identical protein binding activity; translation initiation factor binding activity; and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell differentiation; and response to tumor necrosis factor. Acts upstream of or within several processes, including positive regulation of cytokine-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein ubiquitination. Located in nucleus and striated muscle Myosin thick filament. Is expressed in genitourinary system. Used to study autosomal recessive limb-girdle muscular dystrophy type 2H. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 11; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Orthologous to human TRIM32 (tripartite motif containing 32). [provided by Alliance of Genome Resources, Apr 2022]

Trim32 Products(2)

mRNA	Protein	Name
NM_001161782.1	NP_001155254.1	E3 ubiquitin-protein ligase TRIM32
NM_053084.2	NP_444314.2	E3 ubiquitin-protein ligase TRIM32

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19269368	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	11331580	MGI
enables myosin binding	IPI IPI: Inferred from physical interaction	16243356	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16816390	MGI
enables translation initiation factor binding	IPI IPI: Inferred from physical interaction	16243356	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16243356	MGI
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	22299041	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin ubiquitination	IDA IDA: Inferred from direct assay	16243356	MGI
acts upstream of or within axon development	IMP IMP: Inferred from mutant phenotype	19155210	MGI
involved in fat cell differentiation	IEP IEP: Inferred from expression pattern	17379567	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	21775502	MGI
involved in negative regulation of fibroblast proliferation	IEP IEP: Inferred from expression pattern	19269368	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16816390	MGI
involved in positive regulation of cell motility	IDA IDA: Inferred from direct assay	18632609	MGI
acts upstream of or within positive regulation of chemokine (C-C motif) ligand 20 production	IMP IMP: Inferred from mutant phenotype	20054338	MGI
acts upstream of or within positive regulation of interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20054338	MGI
involved in positive regulation of neurogenesis	IDA IDA: Inferred from direct assay	19269368	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	19269368	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16243356	MGI
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19269368	MGI
acts upstream of or within positive regulation of striated muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22299041	MGI
acts upstream of or within positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20054338	MGI
acts upstream of or within protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	22299041	MGI
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	16243356	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19269368	MGI
involved in response to UV	IDA IDA: Inferred from direct assay	16816390	MGI
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	16816390	MGI
acts upstream of or within tissue homeostasis	IMP IMP: Inferred from mutant phenotype	19155210	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11331580	MGI
located in striated muscle myosin thick filament	IDA IDA: Inferred from direct assay	16243356	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM32

RING-type E3 ubiquitin transferase TRIM32	bM468K2.2 (tripartite motif protein 32)
tripartite motif protein 32	tripartite motif-containing protein 32
zinc finger protein 117

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15037	TRIM32 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21208	Trim32 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27724	Trim32 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim32	NCBI	NCBI:22954

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