2. Gene
  3. Smurf1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

Smurf1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1309707

Gene ID: 690516 | Gene type: protein coding

About Smurf1

Summary

Predicted to enable I-SMAD binding activity; R-SMAD binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including autophagosome assembly; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within negative regulation of ossification. Located in axon and neuronal cell body. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Smurf1 Products(1)

mRNA Protein Name
NM_001109598.1 NP_001103068.1 E3 ubiquitin-protein ligase SMURF1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17728459 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
23226367 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
17728459 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17728459 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SMURF1

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110195 Smurf1-IN-A01 99.81% Unkown
HY-149316 Smurf1-IN-1 Inhibitor 99.47% Unkown
HY-160928 Smurf1 modulator-1 Inhibitor 99.76% Unkown
HY-W998345 SMART1 Inhibitor 99.87% Unkown
HY-169049 Smurf1 ligand 1 / Unkown
HY-RS13459 SMURF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18717 Smurf1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25204 Smurf1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smurf1 NCBI NCBI:57154