2. Gene
  3. SETDB1 - Setdb1 SET domain bifurcated histone lysine methyltransferase 1 Gene

SETDB1 - Setdb1 SET domain bifurcated histone lysine methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 689883 | Gene type: protein coding

About SETDB1

Summary

Predicted to enable DNA binding activity; Histone Methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in response to ethanol and response to vitamin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung Cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

SETDB1 Products(1)

mRNA Protein Name
NM_001271175.1 NP_001258104.1 histone-lysine N-methyltransferase SETDB1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23413810 RGD
involved in response to vitamin IEP
IEP: Inferred from expression pattern
23413810 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETDB1

SET domain, bifurcated 1

histone-lysine N-methyltransferase SETDB1-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141539 SETDB1-TTD-IN-1 99.93% Unkown
HY-141539A SETDB1-TTD-IN-1 TFA 99.77% Unkown
HY-168992 UNC6535 Inhibitor / Unkown
HY-173156 UNC10013 Modulator / Unkown
HY-RS12748 SETDB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16697 Setdb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23131 Setdb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SETDB1 NCBI NCBI:9869