2. Gene
  3. Ucma - upper zone of growth plate and cartilage matrix associated Gene

Ucma - upper zone of growth plate and cartilage matrix associated Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Grp; 1110017I16Rik

Gene ID: 68527 | Gene type: protein coding

About Ucma

Summary

This gene encodes chondrocyte-specific, highly charged proteins that are abundantly expressed during the early stages of chondrogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Despite the implied role in calcification and ossification, mice lacking the encoded protein do not display significant defects in the skeletal development. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo a similar proteolytic processing to generate mature proteins. [provided by RefSeq, Aug 2015]

Ucma Products(4)

mRNA Protein Name
NM_001113558.2 NP_001107030.1 unique cartilage matrix-associated protein isoform b preproprotein
NM_001165932.1 NP_001159404.1 unique cartilage matrix-associated protein isoform c precursor
NM_001311208.1 NP_001298137.1 unique cartilage matrix-associated protein isoform d precursor
NM_026754.3 NP_081030.1 unique cartilage matrix-associated protein isoform a precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
29563538 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
18156182 MGI
acts upstream of osteoblast differentiation IDA
IDA: Inferred from direct assay
18156182 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
29563538 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
18156182 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unique cartilage matrix-associated protein

Gla-rich protein

upper zone of growth plate and cartilage matrix associated protein

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132595 Teprasiran p53 Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15406 UCMA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19968 Ucma Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26471 Ucma Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ucma NCBI NCBI:221044