2. Gene
  3. Rpa1 - replication protein A1 Gene

Rpa1 - replication protein A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rpa; RF-A; RP-A; 70kDa; 5031405K23Rik

Gene ID: 68275 | Gene type: protein coding

About Rpa1

Summary

Enables chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homeostasis of number of cells within a tissue; and in utero embryonic development. Located in lateral element and male germ cell nucleus. Is expressed in respiratory system; submandibular gland; testis; and ventricular layer. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Rpa1 Products(2)

mRNA Protein Name
NM_001164223.1 NP_001157695.1 replication protein A 70 kDa DNA-binding subunit isoform 1
NM_026653.2 NP_080929.1 replication protein A 70 kDa DNA-binding subunit isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
12091911 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
15965476 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
15470499 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
15965476 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
15965476 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15470499 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: Inferred from direct assay
12091911 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15965476 MGI
Cellular Component GO Annotation Evidence Reference Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
12091911 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
18283110 MGI
located in lateral element IDA
IDA: Inferred from direct assay
21743440 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
17696610 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11555636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

replication protein A 70 kDa DNA-binding subunit

RF-A protein 1

RP-A p70

replication factor A protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-155655 JC-229 Inhibitor 97.07% Unkown
HY-RS10837 POLR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12142 RPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17297 Rpa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23752 Rpa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpa1 NCBI NCBI:6117
Canis familiaris Rpa1 NCBI NCBI:100855690
Rattus norvegicus Rpa1 NCBI NCBI:287524