Cert1 - ceramide transporter 1 Gene

Mus musculus

Also known as CERT; GPBP; Col4a3bp; 2810404O15Rik; 9230101K08Rik

Gene ID: 68018 | Gene type: protein coding

About Cert1

Summary

Enables kinase activity. Involved in ER to Golgi ceramide transport. Acts upstream of or within several processes, including ceramide metabolic process; lipid homeostasis; and mitochondrion morphogenesis. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; eye; nervous system; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Apr 2022]

Cert1 Products(2)

mRNA	Protein	Name
NM_001164222.1	NP_001157694.1	ceramide transfer protein isoform 2
NM_023420.2	NP_075909.1	ceramide transfer protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activity	IDA IDA: Inferred from direct assay	11007769	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ER to Golgi ceramide transport	IMP IMP: Inferred from mutant phenotype	24642596	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within ceramide metabolic process	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within lipid homeostasis	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within muscle contraction	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	19139267	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	19139267	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19139267	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	19139267	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ceramide transfer protein

START domain-containing protein 11	ceramide transport protein
collagen type IV alpha-3-binding protein	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
goodpasture antigen-binding protein	procollagen, type IV, alpha 3 (Goodpasture ant

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02542	CERT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20882	Cert1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27399	Cert1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cert1	NCBI	NCBI:10087

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