Dgat2 - diacylglycerol O-acyltransferase 2 Gene

Mus musculus

Also known as ARAT; DGAT-2; 0610010B06Rik

Gene ID: 67800 | Gene type: protein coding

About Dgat2

Summary

Enables 2-acylglycerol O-acyltransferase activity; diacylglycerol O-acyltransferase activity; and protein homodimerization activity. Involved in several processes, including cellular response to oleic acid; diacylglycerol biosynthetic process; and lipid homeostasis. Acts upstream of or within triglyceride biosynthetic process. Located in endoplasmic reticulum; membrane; and perinuclear region of cytoplasm. Is integral component of endoplasmic reticulum membrane. Colocalizes with lipid droplet and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dgat2 Products(1)

mRNA	Protein	Name
NM_026384.3	NP_080660.1	diacylglycerol O-acyltransferase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2-acylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	12077311	MGI
enables diacylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	11481335	MGI
enables diacylglycerol O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	21680734	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	21680734	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oleic acid	IMP IMP: Inferred from mutant phenotype	21680734	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	18252207	MGI
involved in diacylglycerol biosynthetic process	IDA IDA: Inferred from direct assay	23066022	MGI
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	11481335	MGI
involved in fat pad development	IMP IMP: Inferred from mutant phenotype	18252207	MGI
involved in fatty acid homeostasis	IGI IGI: Inferred from genetic interaction	18252207	MGI
involved in intracellular triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	14668353	MGI
involved in lipid storage	IGI IGI: Inferred from genetic interaction	21317108	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	21680734	MGI
involved in long-chain fatty-acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	11481335	MGI
involved in low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	18175806	MGI
involved in regulation of plasma lipoprotein particle levels	IMP IMP: Inferred from mutant phenotype	18252207	MGI
acts upstream of or within triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	11481335	MGI
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	21680734	MGI
acts upstream of or within triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	14668353	MGI
involved in triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	21680734	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19049983	MGI
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21680734	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21680734	MGI
colocalizes with lipid droplet	IDA IDA: Inferred from direct assay	19049983	MGI
located in membrane	IDA IDA: Inferred from direct assay	11481335	MGI
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	19049983	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19049983	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

diacylglycerol O-acyltransferase 2

acyl-CoA retinol O-fatty-acyltransferase	diacylglycerol acyltransferase 2
diglyceride acyltransferase 2	retinol O-fatty-acyltransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108341A	PF-06424439 methanesulfonate	Inhibitor	99.85%	Unkown
HY-32219	T863	Inhibitor	99.83%	Unkown
HY-108341	PF-06424439	Inhibitor	99.89%	Unkown
HY-110381	JNJ-DGAT2-A	Inhibitor	98.26%	Unkown
HY-156259	PF-07202954	Inhibitor	97.04%	Unkown
HY-159698A	IONIS-DGAT 2Rx sodium	Inhibitor	96.10%	Unkown
HY-23199	H2-003	Inhibitor	99.53%	Unkown
HY-118386	H2-005		/	Unkown
HY-145624	Obeversen	Inhibitor	/	Unkown
HY-159698	IONIS-DGAT 2Rx	Inhibitor	/	Unkown
HY-162854	Diacylglycerol acyltransferase inhibitor-2	Inhibitor	/	Unkown
HY-162978	DGAT2-IN-3	Inhibitor	/	Unkown
HY-RS03711	DGAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-169499	(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid		/	Unkown
HY-RS16657	Dgat2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23092	Dgat2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dgat2	NCBI	NCBI:84649

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