Oma1 - OMA1 zinc metallopeptidase Gene

Mus musculus

Also known as MPRP-1; ZMPOMA1; 2010001O09Rik

Gene ID: 67013 | Gene type: protein coding

About Oma1

Summary

Enables metalloendopeptidase activity. Involved in several processes, including diet induced thermogenesis; energy homeostasis; and protein processing. Acts upstream of or within cristae formation. Located in mitochondrial inner membrane. Is expressed in alimentary system; liver lobe; and nose. Orthologous to human OMA1 (OMA1 zinc metallopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Oma1 Products(1)

mRNA	Protein	Name
NM_025909.3	NP_080185.1	metalloendopeptidase OMA1, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	24550258	MGI
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	22433842	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cristae formation	IGI IGI: Inferred from genetic interaction	20038678	MGI
involved in diet induced thermogenesis	IMP IMP: Inferred from mutant phenotype	22433842	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	22433842	MGI
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	22433842	MGI
involved in lipid metabolic process	IMP IMP: Inferred from mutant phenotype	22433842	MGI
involved in mitochondrial protein processing	IDA IDA: Inferred from direct assay	24550258	MGI
acts upstream of or within mitochondrial protein processing	IMP IMP: Inferred from mutant phenotype	20038678	MGI
involved in mitochondrial respiratory chain complex assembly	IMP IMP: Inferred from mutant phenotype	26365306	MGI
acts upstream of or within mitochondrion organization	IGI IGI: Inferred from genetic interaction	20038678	MGI
involved in negative regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	22433842	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	22433842	MGI
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	24550258	MGI
involved in zymogen activation	IDA IDA: Inferred from direct assay	24550258	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	24550258	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	20038678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metalloendopeptidase OMA1, mitochondrial

OMA1 homolog, zinc metallopeptidase

overlapping with the m-AAA protease 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09781	OMA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16953	Oma1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23396	Oma1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oma1	NCBI	NCBI:115209

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