Dspp - dentin sialophosphoprotein Gene

Mus musculus

Also known as Dpp; Dsp; Dmp2; Dmp3

Gene ID: 666279 | Gene type: protein coding

About Dspp

Summary

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta. [provided by RefSeq, Feb 2016]

Dspp Products(1)

mRNA	Protein	Name
NM_010080.3	NP_034210.2	dentin sialophosphoprotein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23525114	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within S-shaped body morphogenesis	IMP IMP: Inferred from mutant phenotype	16937369	MGI
acts upstream of or within ameloblast differentiation	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within amelogenesis	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16937369	MGI
acts upstream of or within cellular response to cell-matrix adhesion	IDA IDA: Inferred from direct assay	17286598	MGI
acts upstream of or within connective tissue development	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within dentinogenesis	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	26972716	MGI
acts upstream of or within gene expression involved in extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	23900597	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	16937369	MGI
acts upstream of or within mandibular condyle articular cartilage development	IMP IMP: Inferred from mutant phenotype	23900597	MGI
acts upstream of or within mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	16937369	MGI
acts upstream of or within negative regulation of bone development	IMP IMP: Inferred from mutant phenotype	26972716	MGI
acts upstream of or within negative regulation of chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within negative regulation of growth plate cartilage chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	26972716	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16937369	MGI
acts upstream of or within odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within odontogenesis	IMP IMP: Inferred from mutant phenotype	25027178	MGI
acts upstream of or within positive regulation of chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	23900597	MGI
acts upstream of or within positive regulation of enamel mineralization	IDA IDA: Inferred from direct assay	16014627	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	19001636	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	25027178	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19001636	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dentin sialophosphoprotein

DMP-3

dentin matrix protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3386A	Selcopintide acetate		99.63%	Unkown
HY-P3386	Selcopintide		/	Unkown
HY-RS04027	DSPP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21329	Dspp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27848	Dspp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dspp	NCBI	NCBI:1834

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