Ireb2 - iron responsive element binding protein 2 Gene

Rattus norvegicus

Also known as Irp2

Gene ID: 64831 | Gene type: protein coding

About Ireb2

Summary

Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; and response to iron ion. Located in axon; cytosol; and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ireb2 Products(1)

mRNA	Protein	Name
NM_022863.2	NP_074054.2	iron-responsive element-binding protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 4 iron, 4 sulfur cluster binding	IDA IDA: Inferred from direct assay	7665579	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	21753061	RGD
enables iron-responsive element binding	IDA IDA: Inferred from direct assay	7665579	RGD
enables regulatory region RNA binding	IPI IPI: Inferred from physical interaction	7523370	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	10889193	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	16135072	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	22159112	RGD
involved in cellular response to iron(III) ion	IDA IDA: Inferred from direct assay	16135072	RGD
involved in cellular response to iron(III) ion	IEP IEP: Inferred from expression pattern	17469137	RGD
involved in cellular response to manganese ion	IDA IDA: Inferred from direct assay	16568477	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	17469137	RGD
involved in cellular response to mercaptoethanol	IDA IDA: Inferred from direct assay	16135072	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	22154532	RGD
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	7523370	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	24184442	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	24024382	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	27925282	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	19943190	RGD
involved in response to iron(III) ion	IDA IDA: Inferred from direct assay	21753061	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	16328268	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	19877527	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	24024381	RGD
involved in skeletal muscle atrophy	IEP IEP: Inferred from expression pattern	23994517	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	12111837	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12111837	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

iron-responsive element-binding protein 2

IRE-BP 2

iron regulatory protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06901	IREB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20966	Ireb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27483	Ireb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ireb2	NCBI	NCBI:3658

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