Wnt5a - Wnt family member 5A Gene

Rattus norvegicus

Gene ID: 64566 | Gene type: protein coding

About Wnt5a

Summary

Predicted to enable protein domain specific binding activity and signaling receptor binding activity. Involved in several processes, including estrous cycle; positive regulation of neuron projection arborization; and response to testosterone. Acts upstream of or within Wnt signaling pathway, planar cell polarity pathway. Located in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt5a Products(1)

mRNA	Protein	Name
NM_022631.3	NP_072153.2	protein Wnt-5a precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IDA IDA: Inferred from direct assay	15537637	RGD
involved in cell differentiation	IEP IEP: Inferred from expression pattern	16780995	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	20126574	RGD
involved in lung alveolus development	IEP IEP: Inferred from expression pattern	17911382	RGD
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	26311509	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26311509	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	16909041	RGD
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15327998	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	25424568	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	25424568	RGD
involved in positive regulation of neuron projection arborization	IGI IGI: Inferred from genetic interaction	25424568	RGD
involved in prostate gland development	IEP IEP: Inferred from expression pattern	19389372	RGD
involved in regulation of postsynaptic specialization assembly	IDA IDA: Inferred from direct assay	19332546	RGD
involved in regulation of postsynaptic specialization assembly	IEP IEP: Inferred from expression pattern	19332546	RGD
involved in regulation of postsynaptic specialization assembly	IMP IMP: Inferred from mutant phenotype	19332546	RGD
involved in regulation of synaptic signaling by nitric oxide	EXP EXP: Inferred from Experiment	26311509	RGD
involved in regulation of synaptic signaling by nitric oxide	IDA IDA: Inferred from direct assay	26311509	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16551644	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17911382	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	17911382	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20006014	RGD
involved in response to quercetin	IEP IEP: Inferred from expression pattern	28032729	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	17218409	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	26311509	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26311509	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16243537	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	26311509	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19332546	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19332546	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-5a

Wnt-5a protein	wingless-related MMTV integration site 5A
wingless-type MMTV integration site 5A	wingless-type MMTV integration site family, member 5A

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1416A	Foxy-5 TFA	Agonist	99.02%	Phase 2
HY-P1416	Foxy-5	Agonist	99.56%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99201	Zilovertamab	Inhibitor	98.21%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123071A	Box5 TFA	Antagonist	99.24%	Unkown
HY-123071	Box5	Antagonist	99.24%	Unkown
HY-12557	γ-Glutamylvaline		99.73%	Unkown
HY-116553	FzM1	Inhibitor	98.62%	Unkown
HY-RS15837	WNT5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P5171	MDGCEL	Antagonist	/	Unkown
HY-RS17616	Wnt5a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24076	Wnt5a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt5a	NCBI	NCBI:7474
Mus musculus	Wnt5a	NCBI	NCBI:22418

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