Wnt5a - wingless-type MMTV integration site family, member 5A Gene

Mus musculus

Also known as Wnt-5a; 8030457G12Rik

Gene ID: 22418 | Gene type: protein coding

About Wnt5a

Summary

Enables Frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including Wnt signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of protein phosphorylation; and regulation of animal organ morphogenesis. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt5a Products(2)

mRNA	Protein	Name
NM_001256224.2	NP_001243153.1	protein Wnt-5a isoform 2 precursor
NM_009524.4	NP_033550.2	protein Wnt-5a isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemoattractant activity involved in axon guidance	IDA IDA: Inferred from direct assay	21106844	MGI
enables cytokine activity	IDA IDA: Inferred from direct assay	18986540	MGI
enables frizzled binding	IDA IDA: Inferred from direct assay	10893270	MGI
enables frizzled binding	IPI IPI: Inferred from physical interaction	10557084	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10866835	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20093360	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	18351662	MGI
acts upstream of or within JNK cascade	IDA IDA: Inferred from direct assay	12839624	MGI
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11092808	MGI
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	23517308	MGI
involved in Wnt signaling pathway, calcium modulating pathway	IDA IDA: Inferred from direct assay	18174455	MGI
acts upstream of or within Wnt signaling pathway, calcium modulating pathway	IMP IMP: Inferred from mutant phenotype	18070933	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IDA IDA: Inferred from direct assay	19056682	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	17433286	MGI
involved in Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	21106844	MGI
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	18953410	MGI
involved in anterior/posterior axis specification, embryo	IDA IDA: Inferred from direct assay	9054360	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15073149	MGI
involved in atrial septum development	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within axis elongation	IMP IMP: Inferred from mutant phenotype	19100728	MGI
involved in axon guidance	IDA IDA: Inferred from direct assay	21483795	MGI
involved in axonogenesis	IDA IDA: Inferred from direct assay	23517308	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17804636	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18929644	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16602827	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	12952940	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17804636	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	17986005	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9160667	MGI
involved in cellular response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	16601243	MGI
acts upstream of or within cervix development	IMP IMP: Inferred from mutant phenotype	15073149	MGI
involved in chemoattraction of serotonergic neuron axon	IDA IDA: Inferred from direct assay	21106844	MGI
involved in chemorepulsion of dopaminergic neuron axon	IDA IDA: Inferred from direct assay	21106844	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	17433286	MGI
acts upstream of or within convergent extension	IMP IMP: Inferred from mutant phenotype	17433286	MGI
acts upstream of or within convergent extension involved in axis elongation	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within convergent extension involved in axis elongation	IMP IMP: Inferred from mutant phenotype	25813538	MGI
acts upstream of or within convergent extension involved in organogenesis	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of cytokine production	IDA IDA: Inferred from direct assay	23677472	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	24091014	MGI
acts upstream of or within development of primary male sexual characteristics	IMP IMP: Inferred from mutant phenotype	19100252	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19300477	MGI
involved in dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	23324743	MGI
acts upstream of or within dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	18953410	MGI
involved in dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	23324743	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	18953410	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	10021340	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	19795512	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	10021340	MGI
acts upstream of or within epithelial cell migration	IMP IMP: Inferred from mutant phenotype	16246260	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	17898001	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17898001	MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation	IDA IDA: Inferred from direct assay	17898001	MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	18953410	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18351662	MGI
acts upstream of or within heart looping	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	9160667	MGI
acts upstream of or within hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	9160667	MGI
acts upstream of or within hindgut morphogenesis	IMP IMP: Inferred from mutant phenotype	18804104	MGI
acts upstream of or within hypophysis morphogenesis	IMP IMP: Inferred from mutant phenotype	15037319	MGI
acts upstream of or within inner ear morphogenesis	IDA IDA: Inferred from direct assay	18991062	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	18991062	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
acts upstream of or within lateral sprouting involved in mammary gland duct morphogenesis	IDA IDA: Inferred from direct assay	17898001	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	19795512	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12142021	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	18804104	MGI
acts upstream of or within mammary gland branching involved in thelarche	IDA IDA: Inferred from direct assay	17898001	MGI
acts upstream of meiotic nuclear division	IGI IGI: Inferred from genetic interaction	20106871	MGI
involved in melanocyte proliferation	IDA IDA: Inferred from direct assay	23569434	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19100728	MGI
acts upstream of or within mesenchymal-epithelial cell signaling	IMP IMP: Inferred from mutant phenotype	15073149	MGI
acts upstream of or within mesodermal to mesenchymal transition involved in gastrulation	IGI IGI: Inferred from genetic interaction	25813538	MGI
involved in midbrain development	IDA IDA: Inferred from direct assay	14557550	MGI
involved in midbrain development	IGI IGI: Inferred from genetic interaction	23324743	MGI
involved in midbrain dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	14557550	MGI
involved in midbrain dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	23324743	MGI
involved in midbrain dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	18953410	MGI
acts upstream of or within midgut development	IMP IMP: Inferred from mutant phenotype	19100728	MGI
acts upstream of or within morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	15073149	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	18351662	MGI
NOT involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15748172	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17244647	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18986540	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16602827	MGI
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17244647	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	12952940	MGI
involved in negative regulation of cell proliferation in midbrain	IMP IMP: Inferred from mutant phenotype	18953410	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	17898001	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17898001	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18351662	MGI
involved in negative regulation of melanin biosynthetic process	IDA IDA: Inferred from direct assay	23569434	MGI
acts upstream of or within negative regulation of prostatic bud formation	IMP IMP: Inferred from mutant phenotype	18804104	MGI
involved in negative regulation of synapse assembly	IDA IDA: Inferred from direct assay	18986540	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	17433286	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	19795512	MGI
involved in neurogenesis	IDA IDA: Inferred from direct assay	14557550	MGI
involved in neuron projection morphogenesis	IDA IDA: Inferred from direct assay	21483795	MGI
acts upstream of or within non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	23677472	MGI
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15748172	MGI
involved in non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20032469	MGI
acts upstream of or within notochord morphogenesis	IGI IGI: Inferred from genetic interaction	25813538	MGI
involved in olfactory bulb interneuron development	IMP IMP: Inferred from mutant phenotype	21539518	MGI
acts upstream of or within paraxial mesoderm formation	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within pericardium morphogenesis	IGI IGI: Inferred from genetic interaction	19795512	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18929644	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	23109420	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	20032469	MGI
acts upstream of or within positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	19300477	MGI
acts upstream of or within positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	19300477	MGI
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21857966	MGI
acts upstream of or within positive regulation of cartilage development	IDA IDA: Inferred from direct assay	18991062	MGI
acts upstream of or within positive regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	18991062	MGI
acts upstream of or within positive regulation of cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	10893270	MGI
acts upstream of or within positive regulation of cytokine production	IDA IDA: Inferred from direct assay	23677472	MGI
acts upstream of or within positive regulation of endocytosis	IDA IDA: Inferred from direct assay	24305805	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19100728	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21857966	MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	9160667	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	18174455	MGI
involved in positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	21857966	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	21857966	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	18174455	MGI
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	18174455	MGI
acts upstream of or within positive regulation of meiotic nuclear division	IGI IGI: Inferred from genetic interaction	20106871	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19100728	MGI
involved in positive regulation of neuron projection arborization	IGI IGI: Inferred from genetic interaction	25424568	MGI
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	21539518	MGI
involved in positive regulation of non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	23569434	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	17986005	MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation	IGI IGI: Inferred from genetic interaction	17986005	MGI
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	23109420	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15143170	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15748172	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	19100728	MGI
acts upstream of or within positive regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	18070933	MGI
involved in positive regulation of timing of anagen	IDA IDA: Inferred from direct assay	24681597	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	21857966	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21857966	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16601243	MGI
acts upstream of or within post-anal tail morphogenesis	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	19795512	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	28069946	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	28069946	MGI
involved in primary heart field specification	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within primitive streak formation	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	17433286	MGI
acts upstream of or within protein phosphorylation	IGI IGI: Inferred from genetic interaction	17898001	MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis	IDA IDA: Inferred from direct assay	17898001	MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis	IGI IGI: Inferred from genetic interaction	17898001	MGI
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21857966	MGI
acts upstream of or within regulation of protein localization	IDA IDA: Inferred from direct assay	24305805	MGI
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	17244647	MGI
involved in secondary heart field specification	IGI IGI: Inferred from genetic interaction	22569553	MGI
acts upstream of or within somite development	IGI IGI: Inferred from genetic interaction	25813538	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	19795512	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	19100728	MGI
acts upstream of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	18070933	MGI
acts upstream of or within tube closure	IMP IMP: Inferred from mutant phenotype	19100728	MGI
acts upstream of or within type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	16246260	MGI
acts upstream of or within urinary bladder development	IMP IMP: Inferred from mutant phenotype	18804104	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	15073149	MGI
acts upstream of or within vagina development	IMP IMP: Inferred from mutant phenotype	15073149	MGI
involved in ventricular septum development	IGI IGI: Inferred from genetic interaction	22569553	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	28069946	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	28069946	MGI
located in cell surface	IDA IDA: Inferred from direct assay	8167409	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	8167409	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28069946	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28069946	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-5a

wingless-related MMTV integration site 5A

Wnt5a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Wnt5a	P22725	Kl	Mus musculus	O35082	Anti Tag CoIP	17690294
Cross	Wnt5a	P22725	WIF1	Homo sapiens	Q9Y5W5	Competition Binding	22986341

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1416A	Foxy-5 TFA	Agonist	99.02%	Phase 2
HY-P1416	Foxy-5	Agonist	99.56%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99201	Zilovertamab	Inhibitor	98.21%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123071A	Box5 TFA	Antagonist	99.24%	Unkown
HY-123071	Box5	Antagonist	99.24%	Unkown
HY-12557	γ-Glutamylvaline		99.73%	Unkown
HY-116553	FzM1	Inhibitor	98.62%	Unkown
HY-RS15837	WNT5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P5171	MDGCEL	Antagonist	/	Unkown
HY-RS17616	Wnt5a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24076	Wnt5a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt5a	NCBI	NCBI:7474

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