2. Gene
  3. Inpp5e - inositol polyphosphate-5-phosphatase E Gene

Inpp5e - inositol polyphosphate-5-phosphatase E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 72kDa; mKIAA0123; 1200002L24Rik

Gene ID: 64436 | Gene type: protein coding

About Inpp5e

Summary

Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within inositol phosphate dephosphorylation; negative regulation of protein localization to cilium; and phosphatidylinositol dephosphorylation. Located in Golgi membrane; axoneme; and nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5e Products(2)

mRNA Protein Name
NM_001290437.1 NP_001277366.1 phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b
NM_033134.3 NP_149125.1 phosphatidylinositol polyphosphate 5-phosphatase type IV isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
10806194 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cilium assembly IDA
IDA: Inferred from direct assay
34093381 MGI
acts upstream of or within negative regulation of protein localization to cilium IMP
IMP: Inferred from mutant phenotype
28154160 MGI
acts upstream of or within phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
10806194 MGI
acts upstream of or within phosphatidylinositol metabolic process IDA
IDA: Inferred from direct assay
10806194 MGI
acts upstream of or within phosphatidylinositol metabolic process IMP
IMP: Inferred from mutant phenotype
28154160 MGI
acts upstream of or within response to inositol IDA
IDA: Inferred from direct assay
34093381 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
10806194 MGI
located in axoneme IDA
IDA: Inferred from direct assay
19668215 MGI
located in cilium IDA
IDA: Inferred from direct assay
28154160 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26051944 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol polyphosphate 5-phosphatase type IV

72 kDa inositol polyphosphate 5-phosphatase

inositol polyphosphate-5-phosphatase, 72 kDa

phosphatidylinositol 4,5-bisphosphate 5-phosphatase

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06830 INPP5E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10770 PMPCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21143 Inpp5e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27660 Inpp5e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp5e NCBI NCBI:56623