Arf1 - ADP-ribosylation factor 1 Gene

Rattus norvegicus

Gene ID: 64310 | Gene type: protein coding

About Arf1

Summary

Enables guanyl ribonucleotide binding activity; magnesium ion binding activity; and Phospholipase D activator activity. Involved in several processes, including Golgi to transport vesicle transport; positive regulation of transport; and postsynapse organization. Located in cytosol and late endosome. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with COPI-coated vesicle; Golgi apparatus; and peroxisomal membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Arf1 Products(3)

mRNA	Protein	Name
NM_001414037.1	NP_001400966.1	ADP-ribosylation factor 1
NM_001414038.1	NP_001400967.1	ADP-ribosylation factor 1
NM_022518.5	NP_071963.1	ADP-ribosylation factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	7552752	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	7552752	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	7552752	RGD
enables phospholipase D activator activity	IDA IDA: Inferred from direct assay	7972129	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23889934	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to transport vesicle transport	IDA IDA: Inferred from direct assay	8978816	RGD
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	23889934	RGD
involved in dendritic spine organization	IMP IMP: Inferred from mutant phenotype	23889934	RGD
involved in long-term synaptic depression	IDA IDA: Inferred from direct assay	23889934	RGD
involved in lysosomal membrane organization	IDA IDA: Inferred from direct assay	9538255	RGD
involved in positive regulation of ER to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	15618550	RGD
involved in positive regulation of calcium ion-dependent exocytosis	IDA IDA: Inferred from direct assay	10657240	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	23889934	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	8294513	RGD
involved in positive regulation of late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	21421027	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	8294513	RGD
involved in positive regulation of sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14563210	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	23889934	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23889934	RGD
involved in regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	23889934	RGD
involved in regulation of phospholipid metabolic process	IDA IDA: Inferred from direct assay	10657240	RGD
involved in regulation of receptor internalization	IDA IDA: Inferred from direct assay	23889934	RGD
involved in synaptic vesicle budding	IMP IMP: Inferred from mutant phenotype	9590176	RGD
involved in very-low-density lipoprotein particle assembly	IMP IMP: Inferred from mutant phenotype	15618550	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in COPI-coated vesicle	IDA IDA: Inferred from direct assay	8496147	RGD
located in Golgi membrane	IDA IDA: Inferred from direct assay	8496147	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23889934	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23889934	RGD
located in late endosome	IDA IDA: Inferred from direct assay	21421027	RGD
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	16100119	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	23889934	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	23889934	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	14684384	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP-ribosylation factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112473	Grassofermata	Inhibitor	99.10%	Unkown
HY-173280	Brefeldin A 4-O-nicotinate	Inhibitor	/	Unkown
HY-P10157	ARF(1-22)		/	Unkown
HY-P10594	Myr-Arf1(2–17)		/	Unkown
HY-RS00894	ARF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10658	ARF1 (2-17)	Inhibitor	/	Unkown
HY-RS17736	Arf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24201	Arf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arf1	NCBI	NCBI:375
Mus musculus	Arf1	NCBI	NCBI:11840

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