Foxb1 - forkhead box B1 Gene

Mus musculus

Also known as C43; Mf3; Twh; Fkh5; Foxb1a; Foxb1b; Hfh-e5.1

Gene ID: 64290 | Gene type: protein coding

About Foxb1

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including mammary gland development; nervous system development; and visual learning. Acts upstream of or within spinal cord development; thalamus development; and urogenital system development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; limb; paraxial mesenchyme; and tail bud. Orthologous to human FOXB1 (forkhead box B1). [provided by Alliance of Genome Resources, Apr 2022]

Foxb1 Products(1)

mRNA	Protein	Name
NM_022378.3	NP_071773.2	forkhead box protein B1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8306889	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon target recognition	IMP IMP: Inferred from mutant phenotype	10662642	MGI
involved in cell migration in diencephalon	IMP IMP: Inferred from mutant phenotype	19046377	MGI
involved in epithelial cell differentiation involved in mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	11170346	MGI
involved in floor plate development	IMP IMP: Inferred from mutant phenotype	18064677	MGI
involved in hypothalamus cell migration	IMP IMP: Inferred from mutant phenotype	19046377	MGI
involved in inferior colliculus development	IMP IMP: Inferred from mutant phenotype	11170346	MGI
involved in lactation	IMP IMP: Inferred from mutant phenotype	11170346	MGI
involved in mammary gland lobule development	IMP IMP: Inferred from mutant phenotype	11170346	MGI
involved in mammillary body development	IEP IEP: Inferred from expression pattern	11170346	MGI
involved in mammillary body development	IMP IMP: Inferred from mutant phenotype	15654859	MGI
involved in mammillothalamic axonal tract development	IMP IMP: Inferred from mutant phenotype	10662642	MGI
involved in midbrain development	IMP IMP: Inferred from mutant phenotype	11170346	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10662642	MGI
involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	18064677	MGI
involved in spinal cord development	IEP IEP: Inferred from expression pattern	11170346	MGI
involved in telencephalon cell migration	IMP IMP: Inferred from mutant phenotype	19046377	MGI
involved in thalamus development	IEP IEP: Inferred from expression pattern	11170346	MGI
involved in urogenital system development	IEP IEP: Inferred from expression pattern	11170346	MGI
involved in visual learning	IMP IMP: Inferred from mutant phenotype	15654859	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8306889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein B1

forkhead box B1a	forkhead box B1b
mesoderm/mesenchyme forkhead 3	transcription factor FKH-5

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05039	FOXB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22512	Foxb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29033	Foxb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxb1	NCBI	NCBI:27023

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