Cttn - cortactin Gene

Rattus norvegicus

Also known as Cttnb

Gene ID: 60465 | Gene type: protein coding

About Cttn

Summary

Enables Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including focal adhesion assembly; modification of postsynaptic actin cytoskeleton; and plasma membrane bounded cell projection organization. Located in cell junction and clathrin-coated pit. Is active in glutamatergic synapse and postsynaptic actin Cytoskeleton. Colocalizes with actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]

Cttn Products(3)

mRNA	Protein	Name
NM_001398643.1	NP_001385572.1	src substrate cortactin isoform 1
NM_001398644.1	NP_001385573.1	src substrate cortactin isoform 3
NM_021868.3	NP_068640.2	src substrate cortactin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Arp2/3 complex binding	IPI IPI: Inferred from physical interaction	18775315	RGD
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	9813110	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15159385	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18768925	RGD
involved in cell motility	IMP IMP: Inferred from mutant phenotype	18768925	RGD
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18768925	RGD
involved in lamellipodium organization	IMP IMP: Inferred from mutant phenotype	18768925	RGD
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	14684878	RGD
involved in modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	14684878	RGD
involved in modification of postsynaptic structure	IDA IDA: Inferred from direct assay	14684878	RGD
involved in modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	14684878	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	21210813	RGD
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	18768925	RGD
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	19373774	RGD
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	12612086	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	19995918	RGD
involved in regulation of axon extension	IMP IMP: Inferred from mutant phenotype	21210813	RGD
involved in regulation of cell projection assembly	IMP IMP: Inferred from mutant phenotype	19373774	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IMP IMP: Inferred from mutant phenotype	18768925	RGD
located in cell junction	IDA IDA: Inferred from direct assay	21210813	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	19995918	RGD
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	18768925	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14684878	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	14684878	RGD
located in growth cone	IDA IDA: Inferred from direct assay	21210813	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	15548644	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	15548644	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	12151401	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

src substrate cortactin

Cttn Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cttn	Q66HL2	Cfl1	Rattus norvegicus	P45592	Anti Bait CoIP	19704022
Intra	Cttn	Q66HL2	Cfl1	Rattus norvegicus	P45592	FRET	19704022

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03350	CTTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22133	Cttn Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28655	Cttn Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cttn	NCBI	NCBI:2017

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