Cfl1 - cofilin 1 Gene

Rattus norvegicus

Gene ID: 29271 | Gene type: protein coding

About Cfl1

Summary

Enables actin filament binding activity; phosphatidylinositol bisphosphate binding activity; and protein Phosphatase binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cellular component organization; and positive regulation of cellular component organization. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in several cellular components, including cofilin-actin rod; growth cone; and lamellipodium. Is active in glutamatergic synapse. Used to study myocardial infarction. Biomarker of several diseases, including epilepsy (multiple); impotence; muscular atrophy; ureteral obstruction; and vitamin B12 deficiency. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cfl1 Products(2)

mRNA	Protein	Name
NM_017147.3	NP_058843.1	cofilin-1
NM_017147.3	NP_058843.1	cofilin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IMP IMP: Inferred from mutant phenotype	12566455	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	24740405	RGD
enables phosphatidylinositol bisphosphate binding	IPI IPI: Inferred from physical interaction	19029335	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19704022	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	26324884	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell projection organization	IDA IDA: Inferred from direct assay	16286931	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	26324884	RGD
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	23704350	RGD
involved in cellular response to ether	IEP IEP: Inferred from expression pattern	24239914	RGD
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	23765104	RGD
involved in cellular response to insulin-like growth factor stimulus	IDA IDA: Inferred from direct assay	24195677	RGD
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	24760020	RGD
involved in cellular response to interleukin-6	IDA IDA: Inferred from direct assay	24760020	RGD
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24760020	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	27073215	RGD
involved in modification of postsynaptic actin cytoskeleton	EXP EXP: Inferred from Experiment	16025109	RGD
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	16025109	RGD
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	16025109	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	16025109	RGD
involved in negative regulation of actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	24093776	RGD
involved in negative regulation of actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	15252126	RGD
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	26169356	RGD
involved in negative regulation of cell motility	IMP IMP: Inferred from mutant phenotype	24093776	RGD
acts upstream of or within negative regulation of cell size	IDA IDA: Inferred from direct assay	16286931	RGD
involved in negative regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	23974706	RGD
involved in negative regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	24093776	RGD
involved in negative regulation of postsynaptic density organization	IMP IMP: Inferred from mutant phenotype	26169356	RGD
involved in negative regulation of unidimensional cell growth	IMP IMP: Inferred from mutant phenotype	24093776	RGD
involved in positive regulation of NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	24089484	RGD
involved in positive regulation of barbed-end actin filament capping	IMP IMP: Inferred from mutant phenotype	23704350	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	24093776	RGD
involved in positive regulation of cell motility	IMP IMP: Inferred from mutant phenotype	24214978	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	25723479	RGD
involved in positive regulation of establishment of cell polarity regulating cell shape	IMP IMP: Inferred from mutant phenotype	26169356	RGD
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	24093776	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	15252126	RGD
involved in positive regulation of protein localization to cell leading edge	IMP IMP: Inferred from mutant phenotype	26324884	RGD
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	24093776	RGD
involved in positive regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	25723479	RGD
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	12566455	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	26678157	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	26678157	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	15252126	RGD
located in cofilin-actin rod	IDA IDA: Inferred from direct assay	24760020	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	24760020	RGD
located in filopodium	IDA IDA: Inferred from direct assay	24515839	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16025109	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16025109	RGD
located in growth cone	IDA IDA: Inferred from direct assay	24515839	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	15252126	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	27642592	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	24515839	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	25708984	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cofilin-1

cofilin 1, non-muscle

Cfl1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cfl1	P45592	Cttn	Rattus norvegicus	Q66HL2	Anti Bait CoIP	19704022
Intra	Cfl1	P45592	Cttn	Rattus norvegicus	Q66HL2	Anti Tag CoIP	19704022

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15700	VPS72 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02568	CFL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18607	Cfl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25093	Cfl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cfl1	NCBI	NCBI:1072

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