Ghrl - ghrelin and obestatin prepropeptide Gene

Rattus norvegicus

Gene ID: 59301 | Gene type: protein coding

About Ghrl

Summary

Enables ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of peptide hormone secretion; and regulation of digestive system process. Acts upstream of or within negative regulation of Insulin secretion. Located in cytoplasm. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of multiple endocrine neoplasia and obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

Ghrl Products(1)

mRNA	Protein	Name
NM_021669.2	NP_067701.1	appetite-regulating hormone preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	10604470	RGD
enables ghrelin receptor binding	IMP IMP: Inferred from mutant phenotype	17109695	RGD
enables growth hormone-releasing hormone activity	IDA IDA: Inferred from direct assay	10604470	RGD
enables hormone activity	IDA IDA: Inferred from direct assay	17109695	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10604470	RGD
involved in gastric acid secretion	IDA IDA: Inferred from direct assay	17705669	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17543279	RGD
acts upstream of or within negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	17130496	RGD
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	19620309	RGD
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	19620309	RGD
involved in positive regulation of adipose tissue development	IDA IDA: Inferred from direct assay	14551228	RGD
involved in positive regulation of appetite	IMP IMP: Inferred from mutant phenotype	15994217	RGD
involved in positive regulation of bone development	IDA IDA: Inferred from direct assay	12960077	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11756331	RGD
involved in positive regulation of eating behavior	IDA IDA: Inferred from direct assay	14551228	RGD
involved in positive regulation of feeding behavior	IDA IDA: Inferred from direct assay	17033095	RGD
involved in positive regulation of gastric mucosal blood circulation	IDA IDA: Inferred from direct assay	17033095	RGD
involved in positive regulation of gastro-intestinal system smooth muscle contraction	IDA IDA: Inferred from direct assay	15890336	RGD
involved in positive regulation of growth	IDA IDA: Inferred from direct assay	12960077	RGD
involved in positive regulation of growth hormone secretion	IDA IDA: Inferred from direct assay	10604470	RGD
involved in positive regulation of growth rate	IDA IDA: Inferred from direct assay	17033095	RGD
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	11756331	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	16647196	RGD
involved in positive regulation of response to food	IDA IDA: Inferred from direct assay	17065340	RGD
involved in positive regulation of small intestinal transit	IDA IDA: Inferred from direct assay	21874246	RGD
involved in positive regulation of small intestine smooth muscle contraction	IDA IDA: Inferred from direct assay	15890336	RGD
involved in positive regulation of sprouting angiogenesis	IDA IDA: Inferred from direct assay	21642627	RGD
involved in positive regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	21642627	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26153524	RGD
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26153524	RGD
involved in regulation of gastric motility	IDA IDA: Inferred from direct assay	23525979	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	22516464	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	22516464	RGD
involved in regulation of response to food	IDA IDA: Inferred from direct assay	17065340	RGD
involved in regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	23525979	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	23525979	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	26512025	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26153524	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	26153524	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22516464	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22516464	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

appetite-regulating hormone

ghrelin/obestatin prepropeptide	growth hormone secretagogue
growth hormone-releasing peptide	motilin-related peptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS05415	GHRL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20741	Ghrl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27253	Ghrl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ghrl	NCBI	NCBI:51738

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