FZD1 - Fzd1 frizzled class receptor 1 Gene

Rattus norvegicus

Gene ID: 58868 | Gene type: protein coding

About FZD1

Summary

Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to vitamin D; lung alveolus development; and positive regulation of DNA-binding transcription factor activity. Located in neuron projection and plasma membrane. Orthologous to human FZD1 (Frizzled class receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

FZD1 Products(1)

mRNA	Protein	Name
NM_021266.3	NP_067089.2	frizzled-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	14688793	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14688793	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	14688793	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14688793	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	10559239	RGD
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	14688793	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	1334084	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	1334084	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	1334084	RGD
involved in lung alveolus development	IEP IEP: Inferred from expression pattern	17911382	RGD
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14688793	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	23825416	RGD
involved in regulation of osteoblast differentiation	IEP IEP: Inferred from expression pattern	1334084	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14688793	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

frizzled-1

Drosophila polarity gene (frizzled) homologue	Drosophila polarity gene homolog 1
frizzled family receptor 1	fz-1
rFz1

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9974	Vantictumab	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05176	FZD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18358	Fzd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24837	Fzd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	FZD1	NCBI	NCBI:8321
Mus musculus	FZD1	NCBI	NCBI:14362

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