2. Gene
  3. Nr1h3 - nuclear receptor subfamily 1, group H, member 3 Gene

Nr1h3 - nuclear receptor subfamily 1, group H, member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as LXRalpha

Gene ID: 58852 | Gene type: protein coding

About Nr1h3

Summary

Enables retinoid X receptor binding activity and sequence-specific DNA binding activity. Involved in several processes, including bile acid signaling pathway; Insulin Receptor signaling pathway; and response to Cholesterol. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and premature menopause. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h3 Products(1)

mRNA Protein Name
NM_031627.2 NP_113815.2 oxysterols receptor LXR-alpha
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
7935418 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
7935418 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7935418 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to starvation IEP
IEP: Inferred from expression pattern
33770194 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
17341476 RGD
involved in insulin receptor signaling pathway IEP
IEP: Inferred from expression pattern
11781314 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
17341476 RGD
involved in regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
26256083 RGD
involved in response to cholesterol IEP
IEP: Inferred from expression pattern
25263431 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25263431 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
21136146 RGD
involved in spleen development IEP
IEP: Inferred from expression pattern
17341476 RGD
involved in thymus development IEP
IEP: Inferred from expression pattern
17341476 RGD
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
17341476 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oxysterols receptor LXR-alpha

RLD-1

liver X receptor alpha

nuclear orphan receptor LXR-alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09530 NR1H3 Human Pre-designed siRNA Set A / Unkown
HY-RS22684 Nr1h3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29198 Nr1h3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1h3 NCBI NCBI:10062