2. Gene
  3. Akr1a1 - aldo-keto reductase family 1, member A1 (aldehyde reductase) Gene

Akr1a1 - aldo-keto reductase family 1, member A1 (aldehyde reductase) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Akr1a4; 2610201A18Rik

Gene ID: 58810 | Gene type: protein coding

About Akr1a1

Summary

Enables L-glucuronate reductase activity; alditol:NADP+ 1-oxidoreductase activity; and glucuronolactone reductase activity. Involved in cellular detoxification of aldehyde. Acts upstream of or within D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and aldehyde catabolic process. Located in apical plasma membrane and cytosol. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Akr1a1 Products(1)

mRNA Protein Name
NM_021473.3 NP_067448.1 aldo-keto reductase family 1 member A1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-glucuronate reductase activity IDA
IDA: Inferred from direct assay
15769935 MGI
enables L-glucuronate reductase activity IMP
IMP: Inferred from mutant phenotype
20410296 MGI
enables S-nitrosoglutathione reductase (NADH) activity IMP
IMP: Inferred from mutant phenotype
31649033 MGI
enables aldose reductase (NADPH) activity IDA
IDA: Inferred from direct assay
14667815 MGI
enables glucuronolactone reductase activity IDA
IDA: Inferred from direct assay
22820017 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within D-glucuronate catabolic process IDA
IDA: Inferred from direct assay
15769935 MGI
involved in D-glucuronate catabolic process to D-xylulose 5-phosphate IDA
IDA: Inferred from direct assay
38160 MGI
acts upstream of or within L-ascorbic acid biosynthetic process IDA
IDA: Inferred from direct assay
15769935 MGI
involved in L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
20410296 MGI
acts upstream of or within aldehyde catabolic process IDA
IDA: Inferred from direct assay
15769935 MGI
involved in cellular detoxification of aldehyde IMP
IMP: Inferred from mutant phenotype
22820017 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15769935 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
38160 MGI
located in cytosol IDA
IDA: Inferred from direct assay
15769935 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16635246 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16635246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member A1

alcohol dehydrogenase

aldehyde reductase

aldo-keto reductase family 1, member A4 (aldehyde reductase)

glucuronate reductase

glucuronolactone reductase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 Inhibitor 99.79% Unkown
HY-N0310 Soyasaponin Bb 99.13% Unkown
HY-114009 AKR1C1-IN-1 Inhibitor 99.38% Unkown
HY-D1341 Coumberone 99.95% Unkown
HY-133708 β-Glucogallin 99.82% Unkown
HY-N8549A 5-Dihydrocortisone ≥99.0% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown
HY-113850 CPSA Inhibitor / Unkown
HY-131586 3,7-Dihydroxyflavone / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-172598 Keap1-Nrf2-IN-28 Inhibitor / Unkown
HY-173132 AKR1Cs-IN-1 Inhibitor / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17921 Akr1a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18415 Akr1d1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24390 Akr1a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24896 Akr1d1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1a1 NCBI NCBI:10327