DDX55 - DEAD-box helicase 55 Gene

Homo sapiens

Gene ID: 57696 | Gene type: protein coding

About DDX55

This gene has 13 transcripts (splice variants), 206 orthologues and 38 paralogues. Ubiquitous expression in lymph node (RPKM 4.3), bone marrow (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]

DDX55 Products(1)

mRNA	Protein	Name
NM_020936.3	NP_065987.1	ATP-dependent RNA helicase DDX55

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX55 Protein Structure

DEAD

Helicase_C

DUF4217

0
100
200
300
400
500
600 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DDX55

DEAD (Asp-Glu-Ala-Asp) box polypeptide 55

DDX55 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX55	Q8NHQ9	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	DDX55	Q8NHQ9	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	DDX55	Q8NHQ9	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	DDX55	Q8NHQ9	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	DDX55	Q8NHQ9	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	DDX55	Q8NHQ9	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	DDX55	Q8NHQ9	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	DDX55	Q8NHQ9	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03660	DDX55 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DDX55	VGNC	VGNC:27977
Macaca mulatta	DDX55	VGNC	VGNC:71681
Felis catus	DDX55	VGNC	VGNC:61416
Mus musculus	DDX55	MGD	MGI:1915098
Rattus norvegicus	DDX55	RGD	RGD:2324094
Canis familiaris	DDX55	VGNC	VGNC:39865

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