Clec4e - C-type lectin domain family 4, member e Gene

Mus musculus

Also known as Mincle; Clecsf9

Gene ID: 56619 | Gene type: protein coding

About Clec4e

Summary

Enables glycolipid binding activity and pattern recognition receptor activity. Involved in Antifungal innate immune response and positive regulation of cytokine production. Acts upstream of or within Fc-gamma Receptor signaling pathway; T cell differentiation involved in immune response; and defense response to bacterium. Is active in phagocytic vesicle membrane and plasma membrane. Orthologous to human CLEC4E (C-type lectin domain family 4 member E). [provided by Alliance of Genome Resources, Apr 2022]

Clec4e Products(1)

mRNA	Protein	Name
NM_019948.2	NP_064332.1	C-type lectin domain family 4 member E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycolipid binding	IPI IPI: Inferred from physical interaction	20008526	MGI
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	20008526	MGI
enables pattern recognition receptor activity	IMP IMP: Inferred from mutant phenotype	18490740	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18776906	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	18776906	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	23602766	MGI
acts upstream of or within T cell differentiation involved in immune response	IMP IMP: Inferred from mutant phenotype	23602766	MGI
involved in antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	18490740	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	23602766	MGI
involved in immune response	IMP IMP: Inferred from mutant phenotype	19171887	MGI
involved in innate immune response	IDA IDA: Inferred from direct assay	20008526	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	23602766	MGI
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	18776906	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	18490740	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	18490740	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member E

C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9	C-type lectin, superfamily member 9
macrophage-inducible C-type lectin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02794	CLEC4E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17848	Clec4e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24316	Clec4e Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clec4e	NCBI	NCBI:26253
Macaca mulatta	Clec4e	NCBI	NCBI:722250

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