Anxa2 - annexin A2 Gene

Rattus norvegicus

Also known as ANX2

Gene ID: 56611 | Gene type: protein coding

About Anxa2

Summary

Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including AnxA2 (annexin A2). [provided by Alliance of Genome Resources, Apr 2022]

Anxa2 Products(1)

mRNA	Protein	Name
NM_019905.1	NP_063970.1	annexin A2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables bone sialoprotein binding	IPI IPI: Inferred from physical interaction	23525114	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	14734570	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	18332131	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in body fluid secretion	IMP IMP: Inferred from mutant phenotype	18332131	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	19193640	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19193640	RGD
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19193640	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	9022675	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	19193640	RGD
located in cytosol	IDA IDA: Inferred from direct assay	14499952	RGD
located in macropinosome	IDA IDA: Inferred from direct assay	19193640	RGD
located in membrane	IDA IDA: Inferred from direct assay	23525114	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14734570	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	23525114	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15823548	RGD
located in ruffle	IDA IDA: Inferred from direct assay	19193640	RGD
located in vesicle	IDA IDA: Inferred from direct assay	19193640	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

annexin A2

PAP-IV	annexin-2
calpactin I heavy chain	calpactin-1 heavy chain
chromobindin-8	lipocortin II
p36	placental anticoagulant protein IV
protein I

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126849	3-Morpholinosydnonimine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Anxa2	NCBI	NCBI:302
Mus musculus	Anxa2	NCBI	NCBI:12306

Name
Email *

	Sorry, but the email address you supplied was invalid.