Dynll1 - dynein light chain LC8-type 1 Gene

Mus musculus

Also known as Pin; Dlc8; Dnclc1

Gene ID: 56455 | Gene type: protein coding

About Dynll1

Summary

Enables dynein intermediate chain binding activity; protein C-terminus binding activity; and protein domain specific binding activity. Acts upstream of or within intraciliary retrograde transport; motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in cytoskeleton; cytosol; and membrane. Part of cytoplasmic dynein complex. Is expressed in several structures, including central nervous system; heart; liver; lung; and sensory organ. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Apr 2022]

Dynll1 Products(1)

mRNA	Protein	Name
NM_019682.5	NP_062656.3	dynein light chain 1, cytoplasmic

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dynein intermediate chain binding	IPI IPI: Inferred from physical interaction	11148215	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11163258	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16098226	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within intraciliary retrograde transport	IMP IMP: Inferred from mutant phenotype	25294941	MGI
acts upstream of or within mitocytosis	IMP IMP: Inferred from mutant phenotype	34048705	MGI
acts upstream of or within motile cilium assembly	IMP IMP: Inferred from mutant phenotype	25294941	MGI
acts upstream of or within positive regulation of non-motile cilium assembly	IGI IGI: Inferred from genetic interaction	25294941	MGI
acts upstream of or within positive regulation of non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	25294941	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	34048705	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytoplasmic dynein complex	IPI IPI: Inferred from physical interaction	25294941	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	15136728	MGI
located in cytosol	IDA IDA: Inferred from direct assay	15136728	MGI
part of dynein complex	IDA IDA: Inferred from direct assay	14561217	MGI
located in membrane	IDA IDA: Inferred from direct assay	15136728	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dynein light chain 1, cytoplasmic

8 kDa dynein light chain	8kD LC
8kDa LC	dynein, cytoplasmic, light chain 1
dynein, cytoplasmic, light peptide	mPIN
protein inhibitor of neuronal nitric oxide synthase	protein inhibitor of nitric oxide synthase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04088	DYNLL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19253	Dynll1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25742	Dynll1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dynll1	NCBI	NCBI:8655

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