Diaph3 - diaphanous related formin 3 Gene

Mus musculus

Also known as Dia2; Drf3; Diap3; p134MDia2; 4930417P13Rik

Gene ID: 56419 | Gene type: protein coding

About Diaph3

Summary

Predicted to enable actin binding activity and small GTPase binding activity. Involved in actin filament polymerization. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; gonad; spleen; and vibrissa. Used to study autosomal dominant auditory neuropathy 1 and congenital dyserythropoietic anemia. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3). [provided by Alliance of Genome Resources, Apr 2022]

Diaph3 Products(1)

mRNA	Protein	Name
NM_019670.2	NP_062644.1	protein diaphanous homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	16556604	MGI
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	16556604	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	18458159	MGI
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	18458159	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15976449	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16556604	MGI
enables protein homodimerization activity	IMP IMP: Inferred from mutant phenotype	18458159	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin crosslink formation	IDA IDA: Inferred from direct assay	18835565	MGI
acts upstream of or within actin crosslink formation	IMP IMP: Inferred from mutant phenotype	18835565	MGI
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	23558171	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	33036023	MGI
acts upstream of or within actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	18264091	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	28255013	MGI
acts upstream of or within actin filament polymerization	IDA IDA: Inferred from direct assay	23034183	MGI
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	23558171	MGI
acts upstream of or within actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23034183	MGI
acts upstream of or within actin nucleation	IDA IDA: Inferred from direct assay	21278336	MGI
acts upstream of or within autophagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	33036023	MGI
acts upstream of or within cell projection organization	IDA IDA: Inferred from direct assay	23441200	MGI
acts upstream of or within chromosome segregation	IMP IMP: Inferred from mutant phenotype	27848932	MGI
acts upstream of or within cytokinesis	IDA IDA: Inferred from direct assay	20660154	MGI
acts upstream of or within cytokinesis	IMP IMP: Inferred from mutant phenotype	24239357	MGI
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	23558171	MGI
acts upstream of or within endosomal transport	IMP IMP: Inferred from mutant phenotype	33036023	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	26471482	MGI
acts upstream of or within erythrocyte enucleation	IMP IMP: Inferred from mutant phenotype	18264091	MGI
acts upstream of or within establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	32576838	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	21278336	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	32576838	MGI
acts upstream of or within head development	IMP IMP: Inferred from mutant phenotype	27848932	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	24239357	MGI
acts upstream of or within inner ear receptor cell differentiation	IDA IDA: Inferred from direct assay	23441200	MGI
acts upstream of or within integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	32576838	MGI
acts upstream of or within macrophage differentiation	IMP IMP: Inferred from mutant phenotype	26471482	MGI
acts upstream of or within microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	24069443	MGI
acts upstream of or within microtubule polymerization	IDA IDA: Inferred from direct assay	18458159	MGI
acts upstream of or within microtubule polymerization	IMP IMP: Inferred from mutant phenotype	18458159	MGI
acts upstream of or within negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	18458159	MGI
acts upstream of or within negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	18458159	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	27848932	MGI
acts upstream of or within organelle organization	IMP IMP: Inferred from mutant phenotype	33036023	MGI
acts upstream of or within podosome assembly	IMP IMP: Inferred from mutant phenotype	15976449	MGI
acts upstream of or within protein-containing complex remodeling	IMP IMP: Inferred from mutant phenotype	33036023	MGI
acts upstream of or within regulation of deacetylase activity	IDA IDA: Inferred from direct assay	15976449	MGI
acts upstream of or within sensory perception of sound	IDA IDA: Inferred from direct assay	23441200	MGI
acts upstream of or within spindle checkpoint signaling	IMP IMP: Inferred from mutant phenotype	27848932	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESCRT I complex	IMP IMP: Inferred from mutant phenotype	33036023	MGI
is active in actin filament bundle	IDA IDA: Inferred from direct assay	16556604	MGI
is active in cleavage furrow	IDA IDA: Inferred from direct assay	20660154	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19117945	MGI
part of filamentous actin	IDA IDA: Inferred from direct assay	18835565	MGI
part of filamentous actin	IMP IMP: Inferred from mutant phenotype	18835565	MGI
is active in microtubule organizing center	IDA IDA: Inferred from direct assay	24069443	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19117945	MGI
is active in ribbon synapse	IDA IDA: Inferred from direct assay	23441200	MGI
is active in spindle pole	IDA IDA: Inferred from direct assay	24069443	MGI
is active in stereocilia tip-link density	IDA IDA: Inferred from direct assay	23441200	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein diaphanous homolog 3

Diaph3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Diaph3	Q9Z207	Abi1	Mus musculus	Q8CBW3	Pull Down	18044991
Intra	Diaph3	Q9Z207	Abi1	Mus musculus	Q8CBW3	Anti Bait CoIP	18044991

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168969	AA-BR-157		/	Unkown
HY-RS03765	DIAPH3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21845	Diaph3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Diaph3	NCBI	NCBI:81624

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