Mettl3 - methyltransferase like 3 Gene

Mus musculus

Also known as M6A; Spo8; 2310024F18Rik

Gene ID: 56335 | Gene type: protein coding

About Mettl3

Summary

Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and gamete generation. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in genitourinary system. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Mettl3 Products(1)

mRNA	Protein	Name
NM_019721.2	NP_062695.2	N6-adenosine-methyltransferase subunit METTL3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA m(6)A methyltransferase activity	IDA IDA: Inferred from direct assay	24394384	MGI
enables mRNA m(6)A methyltransferase activity	IMP IMP: Inferred from mutant phenotype	24209618	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24394384	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA methylation	IMP IMP: Inferred from mutant phenotype	28637692	MGI
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	24209618	MGI
involved in forebrain radial glial cell differentiation	IMP IMP: Inferred from mutant phenotype	28965759	MGI
involved in gliogenesis	IMP IMP: Inferred from mutant phenotype	28965759	MGI
involved in mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	28637692	MGI
involved in mRNA destabilization	IMP IMP: Inferred from mutant phenotype	24394384	MGI
involved in mRNA modification	IDA IDA: Inferred from direct assay	24394384	MGI
involved in mRNA processing	IDA IDA: Inferred from direct assay	28965759	MGI
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	24209618	MGI
NOT involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28637692	MGI
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	25569111	MGI
involved in oogenesis	IMP IMP: Inferred from mutant phenotype	32943573	MGI
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	33020597	MGI
involved in regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	28792938	MGI
involved in regulation of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	28809392	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28809392	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	24394384	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	29547716	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	28914256	MGI
located in nucleus	IDA IDA: Inferred from direct assay	28914256	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

N6-adenosine-methyltransferase subunit METTL3

MT-A70	N6-adenosine-methyltransferase 70 kDa subunit
m6a methyltransferase	methyltransferase-like protein 3

Mettl3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mettl3	Q8C3P7	Mettl14	Mus musculus	Q3UIK4	Anti Bait CoIP	24394384

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-156677	STC-15	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134836	STM2457	Inhibitor	99.86%	Unkown
HY-162080	METTL1-WDR4-IN-1	Inhibitor	98.87%	Unkown
HY-115717	UZH2	Inhibitor	98.91%	Unkown
HY-156773	STM3006	Inhibitor	98.71%	Unkown
HY-160415A	WD6305 TFA	Inhibitor	99.81%	Unkown
HY-W037893	METTL3 activator-1	Activator	99.38%	Unkown
HY-153625	STM2120	Inhibitor	99.92%	Unkown
HY-P10387A	RSM3 TFA	Inhibitor	98.83%	Unkown
HY-158404	METTL3-IN-8	Inhibitor	99.81%	Unkown
HY-P10387	RSM3	Inhibitor	95.73%	Unkown
HY-159604	METTL3-IN-9	Inhibitor	95.30%	Unkown
HY-134673B	UZH1b	Inhibitor	99.75%	Unkown
HY-158403	METTL3-IN-7	Inhibitor	/	Unkown
HY-148467	METTL3-IN-1	Inhibitor	/	Unkown
HY-148468	METTL3-IN-2	Inhibitor	/	Unkown
HY-148469	METTL3-IN-3	Inhibitor	/	Unkown
HY-160415	WD6305	Inhibitor	/	Unkown
HY-156759	METTL3-IN-5	Inhibitor	/	Unkown
HY-W125425	Methyl piperazine-2-carboxylate	Activator	/	Unkown
HY-168878	EP652	Inhibitor	/	Unkown
HY-154997	7OQL	Inhibitor	/	Unkown
HY-162930	PROTAC METTL3 degrader 1	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mettl3	NCBI	NCBI:56339

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