2. Gene
  3. Dbn1 - drebrin 1 Gene

Dbn1 - drebrin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 56320 | Gene type: protein coding

About Dbn1

Summary

Predicted to enable actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; and positive regulation of synaptic plasticity. Acts upstream of or within several processes, including cell communication by chemical coupling; cell communication by electrical coupling; and maintenance of protein location in cell. Located in several cellular components, including gap junction; glutamatergic synapse; and postsynaptic density. Is active in postsynaptic cytosol and postsynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and retina. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dbn1 Products(3)

mRNA Protein Name
NM_001177371.1 NP_001170842.1 drebrin isoform 1
NM_001177372.1 NP_001170843.1 drebrin isoform 2
NM_019813.4 NP_062787.2 drebrin isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15084279 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin filament organization IDA
IDA: Inferred from direct assay
11991718 MGI
acts upstream of or within cell communication by chemical coupling IMP
IMP: Inferred from mutant phenotype
15084279 MGI
acts upstream of or within cell communication by electrical coupling IMP
IMP: Inferred from mutant phenotype
15084279 MGI
involved in generation of neurons IEP
IEP: Inferred from expression pattern
20882566 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
acts upstream of or within maintenance of protein location in cell IMP
IMP: Inferred from mutant phenotype
15084279 MGI
involved in neural precursor cell proliferation IEP
IEP: Inferred from expression pattern
20882566 MGI
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25865831 MGI
involved in positive regulation of receptor localization to synapse IMP
IMP: Inferred from mutant phenotype
25865831 MGI
involved in positive regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
25865831 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11991718 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
15084279 MGI
located in gap junction IDA
IDA: Inferred from direct assay
15084279 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17559090 MGI
located in growth cone IDA
IDA: Inferred from direct assay
24720729 MGI
located in membrane IDA
IDA: Inferred from direct assay
15084279 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15084279 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
17559090 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
17559090 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
17559090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

drebrin

developmentally-regulated brain protein

drebrin A

drebrin E2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03548 DBN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21320 Dbn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27839 Dbn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dbn1 NCBI NCBI:1627