Nupr1 - nuclear protein transcription regulator 1 Gene

Mus musculus

Also known as p8; Com1; 2310032H04Rik

Gene ID: 56312 | Gene type: protein coding

About Nupr1

Summary

Enables acetyltransferase activator activity and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of type B pancreatic cell proliferation; and positive regulation of neuroinflammatory response. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of fibroblast proliferation; and skeletal muscle cell differentiation. Predicted to be located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; jaw; orbito-sphenoid; pancreas; and sensory organ. Used to study Sertoli cell-only syndrome. Orthologous to human NUPR1 (nuclear protein 1, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]

Nupr1 Products(1)

mRNA	Protein	Name
NM_019738.1	NP_062712.1	nuclear protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyltransferase activator activity	IMP IMP: Inferred from mutant phenotype	19723804	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19723804	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19723804	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within acute inflammatory response	IMP IMP: Inferred from mutant phenotype	14660681	MGI
acts upstream of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	11896600	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	11896600	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	11896600	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	18495683	MGI
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20181828	MGI
acts upstream of or within negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19723804	MGI
involved in negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	27451286	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	27451286	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	11896600	MGI
involved in negative regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	23900510	MGI
acts upstream of or within positive regulation of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	11896600	MGI
involved in positive regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	16374777	MGI
acts upstream of or within positive regulation of protein modification process	IMP IMP: Inferred from mutant phenotype	19723804	MGI
acts upstream of or within protein acetylation	IMP IMP: Inferred from mutant phenotype	19723804	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	19723804	MGI
acts upstream of or within regulation of female gonad development	IMP IMP: Inferred from mutant phenotype	18495683	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	14660681	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	19723804	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear protein 1

nuclear transcriptional regulator protein 1

protein p8

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0532A	Trifluoperazine dihydrochloride	99.98%	Unkown
HY-B0532	Trifluoperazine	99.83%	Unkown
HY-B0532B	Trifluoperazine dimaleate	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111838A	ZZW-115 hydrochloride	Inducer	98.09%	Unkown
HY-111838	ZZW-115	Activator	/	Unkown
HY-B0532AS	Trifluoperazine-d3 dihydrochloride		/	Unkown
HY-RS09702	NUPR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17469	Nupr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23927	Nupr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nupr1	NCBI	NCBI:26471

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