XKR8 - XK related 8 Gene

Homo sapiens

Also known as XRG8; hXkr8

Gene ID: 55113 | Gene type: protein coding

About XKR8

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,959,973-27,968,093 (from NCBI)

This gene has 9 transcripts (splice variants), 309 orthologues and 5 paralogues. Ubiquitous expression in placenta (RPKM 5.8), bone marrow (RPKM 5.1) and 25 other tissues.

Summary

Enables phospholipid scramblase activity. Involved in engulfment of apoptotic cell; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of myoblast differentiation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

XKR8 Products(1)

mRNA	Protein	Name
NM_018053.4	NP_060523.2	XK-related protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	23845944	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in engulfment of apoptotic cell	IDA IDA: Inferred from direct assay	23845944	GOA
involved in phosphatidylserine exposure on apoptotic cell surface	IDA IDA: Inferred from direct assay	23845944	GOA
involved in positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	28881496	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	23845944	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XKR8 Protein Structure

XK-related

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

XK-related protein 8

X Kell blood group precursor-related family, member 8

Related Diseases

Diseases

Alias

Scott Syndrome

SCTS	Bdplt7
Prothrombin Consumption Deficiency	Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X
Bleeding Disorder, Platelet-Type, 7	Prothrombin Conversion Defect, Familial
Prothrombin Consumption Inhibitor, Familial	Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X
Familial Prothrombin Consumption Inhibitor	Familial Prothrombin Conversion Defect
Platelet-Type Bleeding Disorder 7	Platelet Factor X Receptor Deficiency
Bleeding Disorder Platelet-Type 7	Prothrombin Consumption Inhibitor Familial
Prothrombin Conversion Defect Familial

Neuroacanthocytosis

Neuroacanthocytosis Syndrome

Mcleod Syndrome

Mcleod Neuroacanthocytosis Syndrome	MLS
X-Linked Mcleod Syndrome	Mcleod Phenotype
Neuroacanthocytosis, Mcleod Type	Mcleod Syndrome With Or Without Chronic Granulomatous Disease
MCLDS	Mcleod Type Neuroacanthocytosis
Mcleod Syndrome With Chronic Granulomatous Disease	Neuroacanthocytosis Mcleod Type
Blood Group Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15881	XKR8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	XKR8	VGNC	VGNC:80404
Rattus norvegicus	XKR8	RGD	RGD:1305649
Mus musculus	XKR8	MGD	MGI:2685877
Macaca mulatta	XKR8	VGNC	VGNC:106531
Canis familiaris	XKR8	VGNC	VGNC:48453
Bos taurus	XKR8	VGNC	VGNC:36990

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