2. Gene
  3. Mefv - Mediterranean fever Gene

Mefv - Mediterranean fever Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FMF; pyrin; TRIM20

Gene ID: 54483 | Gene type: protein coding

About Mefv

Summary

Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including negative regulation of NLRP3 inflammasome complex assembly; negative regulation of cytokine production; and pyroptosome complex assembly. Predicted to act upstream of or within immune system process. Predicted to be located in nucleus. Predicted to be part of microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in bladder; female associated reproductive structure; ureter; and urethra of female. Used to study familial Mediterranean fever. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic Cancer (multiple). Orthologous to human MEFV (MEFV innate immuity regulator, pyrin). [provided by Alliance of Genome Resources, Apr 2022]

Mefv Products(3)

mRNA Protein Name
NM_001161790.1 NP_001155262.1 pyrin isoform 1
NM_001161791.1 NP_001155263.1 pyrin isoform 2
NM_019453.2 NP_062326.2 pyrin isoform 3
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
27270401 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
27270401 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyrin

familial mediterranean fever

marenostrin

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08313 MEFV Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20773 Mefv Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27287 Mefv Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mefv NCBI NCBI:4210