Eif2ak2 - eukaryotic translation initiation factor 2-alpha kinase 2 Gene

Rattus norvegicus

Also known as Pkr; Prkr

Gene ID: 54287 | Gene type: protein coding

About Eif2ak2

Summary

Predicted to enable double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Located in nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak2 Products(1)

mRNA	Protein	Name
NM_019335.2	NP_062208.2	interferon-induced, double-stranded RNA-activated protein kinase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17953670	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18535002	RGD
involved in response to exogenous dsRNA	IEP IEP: Inferred from expression pattern	15920723	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	15630703	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15781241	RGD
involved in response to toxic substance	IMP IMP: Inferred from mutant phenotype	18535002	RGD
involved in response to vitamin E	IPI IPI: Inferred from physical interaction	17953670	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon-induced, double-stranded RNA-activated protein kinase

Protein kinase, interferon-inducible double stranded RNA dependent	eIF-2A protein kinase 2
interferon-inducible RNA-dependent protein kinase	protein kinase R
protein kinase RNA-activated	tyrosine-protein kinase EIF2AK2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04243	EIF2AK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18207	Eif2ak2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24684	Eif2ak2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak2	NCBI	NCBI:5610

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