2. Gene
  3. Furin - furin (paired basic amino acid cleaving enzyme) Gene

Furin - furin (paired basic amino acid cleaving enzyme) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pace; Pcsk3

Gene ID: 54281 | Gene type: protein coding

About Furin

Summary

Enables serine-type endopeptidase activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; and protein processing. Located in Golgi cisterna; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human Furin (Furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Furin Products(1)

mRNA Protein Name
NM_019331.2 NP_062204.2 furin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
15194465 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15194465 RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15194465 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
11861638 RGD
involved in protein processing IMP
IMP: Inferred from mutant phenotype
15194465 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Golgi cisterna IDA
IDA: Inferred from direct assay
16541018 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
16541018 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

furin

Paired basic amino acid cleaving enzyme (furin)

Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)

dibasic-processing enzyme

paired basic amino acid residue-cleaving enzy

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147140 BOS-318 98.45% Unkown
HY-P4548 Boc-Arg-Val-Arg-Arg-AMC hydrochloride 99.18% Unkown
HY-P5062A DEC-RVRK-CMK TFA Inhibitor 96.66% Unkown
HY-110147B SSM3 tetraTFA hydrate ≥99.0% Unkown
HY-P5062 DEC-RVRK-CMK Inhibitor / Unkown
HY-P3797 Furin Substrate / Unkown
HY-110147A SSM3 tetraTFA / Unkown
HY-163738 Furin-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Furin NCBI NCBI:5045
Mus musculus Furin NCBI NCBI:18550